TY - JOUR
T1 - Predictive value of definitely abnormal general movements in the general population
AU - Bouwstra, Hylco
AU - Dijk-Stigter, Geerteke R.
AU - Grooten, Hedwig M. J.
AU - Janssen-Plas, Femke E. M.
AU - Koopmans, Alice J.
AU - Mulder, Christien D.
AU - van Belle, Ans
AU - Hadders-Algra, Mijna
PY - 2010/5
Y1 - 2010/5
N2 - AimDefinitely abnormal general movements in populations of high-risk infants predict serious neurodevelopmental impairment. This study aimed to assess predictive values of definitely abnormal general movements at 3 months for serious neurodevelopmental impairment in a representative sample of the general population.MethodA prospective cohort study of 455 3-month-old infants was performed (241 females, 214 males; mean birthweight 3452g, SD 604g; mean gestational age 39.4wks, SD 1.96; n=32 born preterm). At enrolment, general movement quality was assessed by means of video recording. At 4 years, all participants were reassessed by well-baby health clinicians; if serious neurodevelopmental impairment was identified, clinical records were reviewed. Predictive values of definitely abnormal general movement quality for major neurodevelopmental impairment were calculated.ResultsFive children were diagnosed as having a major neurodevelopmental disorder with serious implications for daily life, including three children with cerebral palsy (CP). Three out of the five had shown definitely abnormal general movements; they had lesions involving the periventricular white matter. Two children did not show definitely abnormal general movements; one had unilateral spastic CP due to a cortical lesion and the other had ataxia due to cerebellar atrophy. The positive predictive value of definitely abnormal general movements for major neurodevelopmental impairment was 18/100, and for CP it was 12/100. Negative predictive values approached 100%.InterpretationThe good predictive value of general movement assessment in high-risk populations cannot be generalized to the general population.
AB - AimDefinitely abnormal general movements in populations of high-risk infants predict serious neurodevelopmental impairment. This study aimed to assess predictive values of definitely abnormal general movements at 3 months for serious neurodevelopmental impairment in a representative sample of the general population.MethodA prospective cohort study of 455 3-month-old infants was performed (241 females, 214 males; mean birthweight 3452g, SD 604g; mean gestational age 39.4wks, SD 1.96; n=32 born preterm). At enrolment, general movement quality was assessed by means of video recording. At 4 years, all participants were reassessed by well-baby health clinicians; if serious neurodevelopmental impairment was identified, clinical records were reviewed. Predictive values of definitely abnormal general movement quality for major neurodevelopmental impairment were calculated.ResultsFive children were diagnosed as having a major neurodevelopmental disorder with serious implications for daily life, including three children with cerebral palsy (CP). Three out of the five had shown definitely abnormal general movements; they had lesions involving the periventricular white matter. Two children did not show definitely abnormal general movements; one had unilateral spastic CP due to a cortical lesion and the other had ataxia due to cerebellar atrophy. The positive predictive value of definitely abnormal general movements for major neurodevelopmental impairment was 18/100, and for CP it was 12/100. Negative predictive values approached 100%.InterpretationThe good predictive value of general movement assessment in high-risk populations cannot be generalized to the general population.
KW - MINOR NEUROLOGICAL DYSFUNCTION
KW - PRETERM INFANTS
KW - CEREBRAL-PALSY
KW - QUALITY
KW - CHILDREN
KW - MOTOR
KW - RISK
U2 - 10.1111/j.1469-8749.2009.03529.x
DO - 10.1111/j.1469-8749.2009.03529.x
M3 - Article
SN - 0012-1622
VL - 52
SP - 456
EP - 461
JO - Developmental Medicine and Child Neurology
JF - Developmental Medicine and Child Neurology
IS - 5
ER -