Predictive value of optical coherence tomographic features in the bevacizumab and ranibizumab in patients with diabetic macular edema (BRDME) study

BRDME Res Grp

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

Purpose: To establish the predictive value of specific optical coherence tomography retinal features on visual outcomes and retinal thickness during anti-vascular endothelial growth factor treatment in patients with diabetic macular edema.

Methods: Post hoc analysis of compound data of a prospective, 6-month, multicenter, randomized controlled trial of 119 patients with diabetic macular edema receiving either intravitreal bevacizumab or ranibizumab were analyzed to assess the associations between baseline retinal morphologic parameters and change in best-corrected visual acuity and central subfield thickness. Based on the study protocol of the core study, best-corrected visual acuity and central subfield thickness were obtained before each mandatory monthly injection during 6 months.

Results: The presence of serous retinal detachment at baseline was associated with significant improvement in best-corrected visual acuity letter score at Month 3 and Month 6 (P <0.001 and P = 0.01, respectively). In addition, the presence of disorganization of retinal inner layers was associated with lower best-corrected visual acuity letter score at Month 3 and Month 6 (P <0.05 and P = 0.01, respectively).

Conclusion: This study found that serous retinal detachment and disorganization of retinal inner layers were associated with different treatment responses to anti-vascular endothelial growth factor therapy in patients with diabetic macular edema.

Original languageEnglish
Pages (from-to)812-819
Number of pages8
JournalRetina-The journal of retinal and vitreous diseases
Volume38
Issue number4
DOIs
Publication statusPublished - Apr-2018

Keywords

  • diabetic retinopathy
  • diabetic macular edema
  • optical coherence tomography
  • bevacizumab
  • ranibizumab
  • disorganization of retinal inner layers
  • external limiting membrane
  • inner-outer segment junction line
  • serous retinal detachment
  • vitreomacular adhesion
  • RETINAL INNER LAYERS
  • VISUAL-ACUITY
  • INTRAVITREAL TRIAMCINOLONE
  • PHOTORECEPTOR INTEGRITY
  • PATTERNS
  • DISORGANIZATION
  • OUTCOMES
  • LASER
  • EYES
  • DEGENERATION

Cite this