Predictive value of serum follicle-stimulating hormone levels in the differentiation between hypogonadotropic hypogonadism and constitutional delay of puberty

RJ Odink*, E Schoute, E Herdes, HA Delemarre-van de Waal

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

Objective: Gonadotropin secretion was evaluated to predict hypogonadotropic hypogonadism (HH) in 36 children suspected of having HH. Methods: LH was measured for 24 h at 10-min intervals, and FSH and estradiol or testosterone at 1-hour intervals. Twenty boys (age 15.7, range 13.2-19.3 years) and 16 girls (age 16.1, range 13.0-20.6 years) were studied. Results: LH pulses were detected in 9 boys and 5 girls. HH was confirmed in all 11 LH apulsatile boys and in 8 of 11 LH apulsatile girls. Random FSH values of less than or equal to 1.11 and less than or equal to 2.86 IU/1 in boys and girls, respectively, discriminated patients with LH pulses from patients without (sensitivity for lack of LH pulses 97 and 100%, respectively). In boys testicular volume was not discriminatory. In 1 girl LH pulses were observed without estradiol production, suggesting LH neurosecretory dysfunction. Conclusions: Low FSH levels in adolescence are strongly related to a lack of LH pulses. Lack of LH pulses is highly suspect for HH. FSH may be a tool in the differentiation between HH and delayed puberty.

Original languageEnglish
Pages (from-to)279-287
Number of pages9
JournalHORMONE RESEARCH
Volume49
Issue number6
Publication statusPublished - Jun-1998

Keywords

  • hypogonadotropic hypogonadism
  • follicle-stimulating hormone
  • luteinizing hormone pulse
  • GONADOTROPIN-RELEASING-HORMONE
  • SENSITIVE IMMUNORADIOMETRIC ASSAYS
  • RESOLVED IMMUNOFLUOROMETRIC ASSAY
  • LUTEINIZING-HORMONE
  • NEUROSECRETORY DYSFUNCTION
  • SECRETION PATTERNS
  • PULSATILE
  • GIRLS
  • GROWTH
  • BOYS

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