Predictors of All-Cause Mortality in Patients with Stable COPD: Medical Co-morbid Conditions or High Depressive Symptoms

Gemma A. Maters*, Jacob N. de Voogd, Robbert Sanderman, Johan B. Wempe

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Co-morbid conditions are frequently found in patients with COPD. We evaluate the association of co-morbidities with mortality, in stable COPD. 224 patients, mean age 61.2 (+/- 10.00), 48.2% female, mean FEV1 1.1 (+/- 0.5) liters, median follow-up time 4.2 years, participated. Medical co-morbidities were scored according to the Charlson Co-morbidity Index (CCI). Depressive symptoms were assessed with the Hospital Anxiety and Depression Scale (HADS) and Symptom Checklist-90 (SCL-90). The Cox proportional hazard model was used for survival analyses. In our sample, 70% of all patients have a co-morbid medical condition or high depressive symptoms. During follow-up 51% of all patients died, and those with heart failure have the highest mortality rate (75%). Age, fat-free mass and exercise capacity were predictive factors, contrary to CCI-scores and high depressive symptoms. An unadjusted association between heart failure and survival was found. Although the presence of co-morbidities, using the CCI-score, is not related to survival, heart failure seems to have a detrimental effect on survival. Higher age and lower exercise capacity or fat-free mass predict mortality.

Original languageEnglish
Pages (from-to)468-474
Number of pages7
JournalCOPD: Journal of Chronic Obstructive Pulmonary Disease
Volume11
Issue number4
DOIs
Publication statusPublished - Aug-2014

Keywords

  • co-morbidity
  • depression
  • heart failure
  • survival
  • OBSTRUCTIVE PULMONARY-DISEASE
  • SHUTTLE WALKING TEST
  • ACUTE EXACERBATION
  • PROSPECTIVE COHORT
  • PRIMARY-CARE
  • BODY-MASS
  • COMORBIDITIES
  • HOSPITALIZATIONS
  • REHABILITATION
  • VALIDATION

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