Abstract
Co-morbid conditions are frequently found in patients with COPD. We evaluate the association of co-morbidities with mortality, in stable COPD. 224 patients, mean age 61.2 (+/- 10.00), 48.2% female, mean FEV1 1.1 (+/- 0.5) liters, median follow-up time 4.2 years, participated. Medical co-morbidities were scored according to the Charlson Co-morbidity Index (CCI). Depressive symptoms were assessed with the Hospital Anxiety and Depression Scale (HADS) and Symptom Checklist-90 (SCL-90). The Cox proportional hazard model was used for survival analyses. In our sample, 70% of all patients have a co-morbid medical condition or high depressive symptoms. During follow-up 51% of all patients died, and those with heart failure have the highest mortality rate (75%). Age, fat-free mass and exercise capacity were predictive factors, contrary to CCI-scores and high depressive symptoms. An unadjusted association between heart failure and survival was found. Although the presence of co-morbidities, using the CCI-score, is not related to survival, heart failure seems to have a detrimental effect on survival. Higher age and lower exercise capacity or fat-free mass predict mortality.
Original language | English |
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Pages (from-to) | 468-474 |
Number of pages | 7 |
Journal | COPD: Journal of Chronic Obstructive Pulmonary Disease |
Volume | 11 |
Issue number | 4 |
DOIs | |
Publication status | Published - Aug-2014 |
Keywords
- co-morbidity
- depression
- heart failure
- survival
- OBSTRUCTIVE PULMONARY-DISEASE
- SHUTTLE WALKING TEST
- ACUTE EXACERBATION
- PROSPECTIVE COHORT
- PRIMARY-CARE
- BODY-MASS
- COMORBIDITIES
- HOSPITALIZATIONS
- REHABILITATION
- VALIDATION