Predictors of clinical response to extrafine and non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma

Fajri Gafar, Ilse M. Boudewijn*, Claire A. Cox, Judith M. Vonk, Siebrig Schokker, Anne J. Lexmond, Henderik W. Frijlink, Paul Hagedoorn, Dirkje S. Postma, Maarten van den Berge

*Corresponding author for this work

Research output: Contribution to journalLetterAcademicpeer-review

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Abstract

We performed a post-hoc analysis of the OLiVIA-study investigating whether current and ex-smoking asthmatics with small airways dysfunction (SAD) show a better response in airway hyperresponsiveness (AHR) to small particle adenosine after treatment with extrafine compared to non-extrafine particle inhaled corticosteroids (ICS), and to investigate which clinical parameters predict a favorable response to both treatments. We show that smoking and ex-smoking asthmatics with and without SAD have a similar treatment response with either extrafine or non-extrafine particle ICS. We also found that lower blood neutrophils are associated with a smaller ICS-response in smokers and ex-smokers with asthma, independent from the level of blood eosinophils.

Original languageEnglish
Article number256
Number of pages5
JournalRespiratory Research
Volume19
Issue number1
DOIs
Publication statusPublished - 18-Dec-2018

Keywords

  • Asthma
  • Inhaled corticosteroids
  • Extrafine particle
  • Non-extrafine particle
  • Small airways
  • Smoking
  • DYSFUNCTION

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