Abstract
We performed a post-hoc analysis of the OLiVIA-study investigating whether current and ex-smoking asthmatics with small airways dysfunction (SAD) show a better response in airway hyperresponsiveness (AHR) to small particle adenosine after treatment with extrafine compared to non-extrafine particle inhaled corticosteroids (ICS), and to investigate which clinical parameters predict a favorable response to both treatments. We show that smoking and ex-smoking asthmatics with and without SAD have a similar treatment response with either extrafine or non-extrafine particle ICS. We also found that lower blood neutrophils are associated with a smaller ICS-response in smokers and ex-smokers with asthma, independent from the level of blood eosinophils.
Original language | English |
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Article number | 256 |
Number of pages | 5 |
Journal | Respiratory Research |
Volume | 19 |
Issue number | 1 |
DOIs | |
Publication status | Published - 18-Dec-2018 |
Keywords
- Asthma
- Inhaled corticosteroids
- Extrafine particle
- Non-extrafine particle
- Small airways
- Smoking
- DYSFUNCTION