Predictors of sudden cardiac death after mustard or senning repair for transposition of the great arteries

JAE Kammeraad; CHM van Deurzen; N Sreeram; MTE Bink-Boelkens; J Ottenkamp; WA Helbing; J Lam; MA Sobotka-Plojhar; O Daniels; S Balaji

doi:10.1016/j.jace.2004.05.073

Predictors of sudden cardiac death after mustard or senning repair for transposition of the great arteries

JAE Kammeraad, CHM van Deurzen, N Sreeram, MTE Bink-Boelkens, J Ottenkamp, WA Helbing, J Lam, MA Sobotka-Plojhar, O Daniels, S Balaji^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

265 Citations (Scopus)

Abstract

OBJECTIVES The goal of this research was to identify predictors for sudden death (SD) in patients with transposition of the great arteries (TGA) who have undergone atrial inflow repair.

BACKGROUND Sudden death is the most common cause of late death after atrial inflow repair of TGA. Little is known about the predictors of SD.

METHODS This was a retrospective, multicenter, case-controtled study. We identified 47 patients after Mustard's or Senning's operation who experienced an SD event (34 SD, 13 near-miss SD). Each patient was matched with two controls with the same operation, but without an SD event. Information on numerous variables before the event was obtained and compared with controls at the same time frame.

RESULTS Presence of symptoms of arrhythmia or heart failure at most recent follow-up and history of documented arrhythmia (atrial flutter [AFL]/atrial fibrillation [AF]) were found to increase the risk of SD. Electrocardiogram (ECG), chest X-ray, and Holter ECG findings were not predictive of SD. Neither medication nor pacing was found to be protective. Most SD events (81%) occurred during exercise. Ventricular tachycardia/ventricular fibrillation were the recorded rhythm during SD in 21 of 47 patients.

CONCLUSIONS Presence of symptoms and documented AFL/AF are the best predictors of SD in TGA patients. Patients with these findings should be further evaluated for risk of SD. (C) 2004 by the American College of Cardiology Foundation.

Original language	English
Pages (from-to)	1095-1102
Number of pages	8
Journal	Journal of the American College of Cardiology
Volume	44
Issue number	5
DOIs	https://doi.org/10.1016/j.jace.2004.05.073
Publication status	Published - 1-Sept-2004

Keywords

CONGENITAL HEART-DISEASE
INTRAATRIAL REENTRANT TACHYCARDIA
RIGHT-VENTRICULAR DYSFUNCTION
TERM FOLLOW-UP
LONG-TERM
RADIOFREQUENCY ABLATION
ATRIAL REPAIR
RISK-FACTORS
OPERATION
ARRHYTHMIA

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Kammeraad, JAE., van Deurzen, CHM., Sreeram, N., Bink-Boelkens, MTE., Ottenkamp, J., Helbing, WA., Lam, J., Sobotka-Plojhar, MA., Daniels, O., & Balaji, S. (2004). Predictors of sudden cardiac death after mustard or senning repair for transposition of the great arteries. Journal of the American College of Cardiology, 44(5), 1095-1102. https://doi.org/10.1016/j.jace.2004.05.073

@article{c7564f90d7004dcd8e6c45605f449c35,

title = "Predictors of sudden cardiac death after mustard or senning repair for transposition of the great arteries",

abstract = "OBJECTIVES The goal of this research was to identify predictors for sudden death (SD) in patients with transposition of the great arteries (TGA) who have undergone atrial inflow repair.BACKGROUND Sudden death is the most common cause of late death after atrial inflow repair of TGA. Little is known about the predictors of SD.METHODS This was a retrospective, multicenter, case-controtled study. We identified 47 patients after Mustard's or Senning's operation who experienced an SD event (34 SD, 13 near-miss SD). Each patient was matched with two controls with the same operation, but without an SD event. Information on numerous variables before the event was obtained and compared with controls at the same time frame.RESULTS Presence of symptoms of arrhythmia or heart failure at most recent follow-up and history of documented arrhythmia (atrial flutter [AFL]/atrial fibrillation [AF]) were found to increase the risk of SD. Electrocardiogram (ECG), chest X-ray, and Holter ECG findings were not predictive of SD. Neither medication nor pacing was found to be protective. Most SD events (81\%) occurred during exercise. Ventricular tachycardia/ventricular fibrillation were the recorded rhythm during SD in 21 of 47 patients.CONCLUSIONS Presence of symptoms and documented AFL/AF are the best predictors of SD in TGA patients. Patients with these findings should be further evaluated for risk of SD. (C) 2004 by the American College of Cardiology Foundation.",

keywords = "CONGENITAL HEART-DISEASE, INTRAATRIAL REENTRANT TACHYCARDIA, RIGHT-VENTRICULAR DYSFUNCTION, TERM FOLLOW-UP, LONG-TERM, RADIOFREQUENCY ABLATION, ATRIAL REPAIR, RISK-FACTORS, OPERATION, ARRHYTHMIA",

author = "JAE Kammeraad and \{van Deurzen\}, CHM and N Sreeram and MTE Bink-Boelkens and J Ottenkamp and WA Helbing and J Lam and MA Sobotka-Plojhar and O Daniels and S Balaji",

year = "2004",

month = sep,

day = "1",

doi = "10.1016/j.jace.2004.05.073",

language = "English",

volume = "44",

pages = "1095--1102",

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issn = "0735-1097",

publisher = "ELSEVIER SCIENCE INC",

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}

Kammeraad, JAE, van Deurzen, CHM, Sreeram, N, Bink-Boelkens, MTE, Ottenkamp, J, Helbing, WA, Lam, J, Sobotka-Plojhar, MA, Daniels, O & Balaji, S 2004, 'Predictors of sudden cardiac death after mustard or senning repair for transposition of the great arteries', Journal of the American College of Cardiology, vol. 44, no. 5, pp. 1095-1102. https://doi.org/10.1016/j.jace.2004.05.073

TY - JOUR

T1 - Predictors of sudden cardiac death after mustard or senning repair for transposition of the great arteries

AU - Kammeraad, JAE

AU - van Deurzen, CHM

AU - Sreeram, N

AU - Bink-Boelkens, MTE

AU - Ottenkamp, J

AU - Helbing, WA

AU - Lam, J

AU - Sobotka-Plojhar, MA

AU - Daniels, O

AU - Balaji, S

PY - 2004/9/1

Y1 - 2004/9/1

N2 - OBJECTIVES The goal of this research was to identify predictors for sudden death (SD) in patients with transposition of the great arteries (TGA) who have undergone atrial inflow repair.BACKGROUND Sudden death is the most common cause of late death after atrial inflow repair of TGA. Little is known about the predictors of SD.METHODS This was a retrospective, multicenter, case-controtled study. We identified 47 patients after Mustard's or Senning's operation who experienced an SD event (34 SD, 13 near-miss SD). Each patient was matched with two controls with the same operation, but without an SD event. Information on numerous variables before the event was obtained and compared with controls at the same time frame.RESULTS Presence of symptoms of arrhythmia or heart failure at most recent follow-up and history of documented arrhythmia (atrial flutter [AFL]/atrial fibrillation [AF]) were found to increase the risk of SD. Electrocardiogram (ECG), chest X-ray, and Holter ECG findings were not predictive of SD. Neither medication nor pacing was found to be protective. Most SD events (81%) occurred during exercise. Ventricular tachycardia/ventricular fibrillation were the recorded rhythm during SD in 21 of 47 patients.CONCLUSIONS Presence of symptoms and documented AFL/AF are the best predictors of SD in TGA patients. Patients with these findings should be further evaluated for risk of SD. (C) 2004 by the American College of Cardiology Foundation.

AB - OBJECTIVES The goal of this research was to identify predictors for sudden death (SD) in patients with transposition of the great arteries (TGA) who have undergone atrial inflow repair.BACKGROUND Sudden death is the most common cause of late death after atrial inflow repair of TGA. Little is known about the predictors of SD.METHODS This was a retrospective, multicenter, case-controtled study. We identified 47 patients after Mustard's or Senning's operation who experienced an SD event (34 SD, 13 near-miss SD). Each patient was matched with two controls with the same operation, but without an SD event. Information on numerous variables before the event was obtained and compared with controls at the same time frame.RESULTS Presence of symptoms of arrhythmia or heart failure at most recent follow-up and history of documented arrhythmia (atrial flutter [AFL]/atrial fibrillation [AF]) were found to increase the risk of SD. Electrocardiogram (ECG), chest X-ray, and Holter ECG findings were not predictive of SD. Neither medication nor pacing was found to be protective. Most SD events (81%) occurred during exercise. Ventricular tachycardia/ventricular fibrillation were the recorded rhythm during SD in 21 of 47 patients.CONCLUSIONS Presence of symptoms and documented AFL/AF are the best predictors of SD in TGA patients. Patients with these findings should be further evaluated for risk of SD. (C) 2004 by the American College of Cardiology Foundation.

KW - CONGENITAL HEART-DISEASE

KW - INTRAATRIAL REENTRANT TACHYCARDIA

KW - RIGHT-VENTRICULAR DYSFUNCTION

KW - TERM FOLLOW-UP

KW - LONG-TERM

KW - RADIOFREQUENCY ABLATION

KW - ATRIAL REPAIR

KW - RISK-FACTORS

KW - OPERATION

KW - ARRHYTHMIA

U2 - 10.1016/j.jace.2004.05.073

DO - 10.1016/j.jace.2004.05.073

M3 - Article

SN - 0735-1097

VL - 44

SP - 1095

EP - 1102

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 5

ER -

Predictors of sudden cardiac death after mustard or senning repair for transposition of the great arteries

Abstract

Keywords

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