Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system

MD Waldinger*, H H G Berendsen, BFM Blok, B Olivier, G Holstege

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    285 Citations (Scopus)

    Abstract

    Premature ejaculation has generally been considered a psychosexual disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SSRIs) in delaying ejaculation We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A. hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated. (C) 1998 Elsevier Science B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)111-118
    Number of pages8
    JournalBehavioural Brain Research
    Volume92
    Issue number2
    DOIs
    Publication statusPublished - May-1998

    Keywords

    • premature ejaculation
    • serotonergic antidepressants
    • sexual dysfunction
    • PENILE ERECTIONS
    • SEXUAL-BEHAVIOR
    • DOUBLE-BLIND
    • RECEPTORS
    • 5-HYDROXYTRYPTAMINE
    • CLOMIPRAMINE
    • 5-HT
    • RATS
    • ANTAGONISTS
    • AGONISTS

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