Abstract
Premature ejaculation has generally been considered a psychosexual disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SSRIs) in delaying ejaculation We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A. hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated. (C) 1998 Elsevier Science B.V. All rights reserved.
Original language | English |
---|---|
Pages (from-to) | 111-118 |
Number of pages | 8 |
Journal | Behavioural Brain Research |
Volume | 92 |
Issue number | 2 |
DOIs | |
Publication status | Published - May-1998 |
Keywords
- premature ejaculation
- serotonergic antidepressants
- sexual dysfunction
- PENILE ERECTIONS
- SEXUAL-BEHAVIOR
- DOUBLE-BLIND
- RECEPTORS
- 5-HYDROXYTRYPTAMINE
- CLOMIPRAMINE
- 5-HT
- RATS
- ANTAGONISTS
- AGONISTS