Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior: considerations for neurodevelopmental diseases

M Fiore; J Korf; F Angelucci; L Talamini; L Aloe

Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior: considerations for neurodevelopmental diseases

M Fiore
, J Korf^*
, F Angelucci
, L Talamini
, L Aloe

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

37 Citations (Scopus)

Abstract

We did a single injection of methylazoxymethanol acetate (MAM) in pregnant rats on gestational day (GD) 11 or 12 to investigate the long-lasting effects of early entorhinal cortex (EC) and hippocampus maldevelopment on behavior, brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels, and the neurotrophin receptor p75 and choline acetyltransferase (ChAT) immunoreactivity. Adult animals treated with MAM had compromised EC development and showed changes in locomotion and displacement activities. In addition, rats treated on GD 12 had increased concentration of NGF and BDNF in the EC and hippocampus if compared to control rats. Prenatal MAM administration did not affect significantly p75 and ChAT distribution in the EC and septum. Results are discussed in reference to the neurodevelopmental hypothesis of psychiatric disorders. (C) 2000 Elsevier Science Inc. All rights reserved.

Original language	English
Pages (from-to)	57-67
Number of pages	11
Journal	Physiology & Behavior
Volume	71
Issue number	1-2
Publication status	Published - 1-Oct-2000

Keywords

NGF
BDNF
behavior
schizophrenia
ChAT
p75
NERVE GROWTH-FACTOR
ENTORHINAL CORTEX LESIONS
CHAT IMMUNOREACTIVITY
MICROENCEPHALIC RATS
SCHIZOPHRENIC WOMEN
NEURONAL DEATH
MESSENGER-RNA
BRAIN
NGF
ADULT

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title = "Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior: considerations for neurodevelopmental diseases",

abstract = "We did a single injection of methylazoxymethanol acetate (MAM) in pregnant rats on gestational day (GD) 11 or 12 to investigate the long-lasting effects of early entorhinal cortex (EC) and hippocampus maldevelopment on behavior, brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels, and the neurotrophin receptor p75 and choline acetyltransferase (ChAT) immunoreactivity. Adult animals treated with MAM had compromised EC development and showed changes in locomotion and displacement activities. In addition, rats treated on GD 12 had increased concentration of NGF and BDNF in the EC and hippocampus if compared to control rats. Prenatal MAM administration did not affect significantly p75 and ChAT distribution in the EC and septum. Results are discussed in reference to the neurodevelopmental hypothesis of psychiatric disorders. (C) 2000 Elsevier Science Inc. All rights reserved.",

keywords = "NGF, BDNF, behavior, schizophrenia, ChAT, p75, NERVE GROWTH-FACTOR, ENTORHINAL CORTEX LESIONS, CHAT IMMUNOREACTIVITY, MICROENCEPHALIC RATS, SCHIZOPHRENIC WOMEN, NEURONAL DEATH, MESSENGER-RNA, BRAIN, NGF, ADULT",

author = "M Fiore and J Korf and F Angelucci and L Talamini and L Aloe",

year = "2000",

month = oct,

day = "1",

language = "English",

volume = "71",

pages = "57--67",

journal = "Physiology \& Behavior",

issn = "0031-9384",

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TY - JOUR

T1 - Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior

T2 - considerations for neurodevelopmental diseases

AU - Fiore, M

AU - Korf, J

AU - Angelucci, F

AU - Talamini, L

AU - Aloe, L

PY - 2000/10/1

Y1 - 2000/10/1

N2 - We did a single injection of methylazoxymethanol acetate (MAM) in pregnant rats on gestational day (GD) 11 or 12 to investigate the long-lasting effects of early entorhinal cortex (EC) and hippocampus maldevelopment on behavior, brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels, and the neurotrophin receptor p75 and choline acetyltransferase (ChAT) immunoreactivity. Adult animals treated with MAM had compromised EC development and showed changes in locomotion and displacement activities. In addition, rats treated on GD 12 had increased concentration of NGF and BDNF in the EC and hippocampus if compared to control rats. Prenatal MAM administration did not affect significantly p75 and ChAT distribution in the EC and septum. Results are discussed in reference to the neurodevelopmental hypothesis of psychiatric disorders. (C) 2000 Elsevier Science Inc. All rights reserved.

AB - We did a single injection of methylazoxymethanol acetate (MAM) in pregnant rats on gestational day (GD) 11 or 12 to investigate the long-lasting effects of early entorhinal cortex (EC) and hippocampus maldevelopment on behavior, brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels, and the neurotrophin receptor p75 and choline acetyltransferase (ChAT) immunoreactivity. Adult animals treated with MAM had compromised EC development and showed changes in locomotion and displacement activities. In addition, rats treated on GD 12 had increased concentration of NGF and BDNF in the EC and hippocampus if compared to control rats. Prenatal MAM administration did not affect significantly p75 and ChAT distribution in the EC and septum. Results are discussed in reference to the neurodevelopmental hypothesis of psychiatric disorders. (C) 2000 Elsevier Science Inc. All rights reserved.

KW - NGF

KW - BDNF

KW - behavior

KW - schizophrenia

KW - ChAT

KW - p75

KW - NERVE GROWTH-FACTOR

KW - ENTORHINAL CORTEX LESIONS

KW - CHAT IMMUNOREACTIVITY

KW - MICROENCEPHALIC RATS

KW - SCHIZOPHRENIC WOMEN

KW - NEURONAL DEATH

KW - MESSENGER-RNA

KW - BRAIN

KW - NGF

KW - ADULT

M3 - Article

SN - 0031-9384

VL - 71

SP - 57

EP - 67

JO - Physiology & Behavior

JF - Physiology & Behavior

IS - 1-2

ER -

Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior: considerations for neurodevelopmental diseases

Abstract

Keywords

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