TY - JOUR
T1 - Prenatal Particulate Air Pollution and DNA Methylation in Newborns
T2 - An Epigenome-Wide Meta-Analysis
AU - Biobank-based Integrative Omics
AU - Gruzieva, Olena
AU - Xu, Cheng-Jian
AU - Yousefi, Paul
AU - Relton, Caroline
AU - Merid, Simon Kebede
AU - Breton, Carrie V.
AU - Gao, Lu
AU - Volk, Heather E.
AU - Feinberg, Jason I.
AU - Ladd-Acosta, Christine
AU - Bakulski, Kelly
AU - Auffray, Charles
AU - Lemonnier, Nathanael
AU - Plusquin, Michelle
AU - Ghantous, Akram
AU - Herceg, Zdenko
AU - Nawrot, Tim S.
AU - Pizzi, Costanza
AU - Richiardi, Lorenzo
AU - Rusconi, Franca
AU - Vineis, Paolo
AU - Kogevinas, Manolis
AU - Felix, Janine F.
AU - Duijts, Liesbeth
AU - den Dekker, Herman T.
AU - Jaddoe, Vincent W. V.
AU - Ruiz, Jose L.
AU - Bustamante, Mariona
AU - Anto, Josep Maria
AU - Sunyer, Jordi
AU - Vrijheid, Martine
AU - Gutzkow, Kristine B.
AU - Grazuleviciene, Regina
AU - Hernandez-Ferrer, Carles
AU - Annesi-Maesano, Isabella
AU - Lepeule, Johanna
AU - Bousquet, Jean
AU - Bergstrom, Anna
AU - Kull, Inger
AU - Soderhall, Cilla
AU - Kere, Juha
AU - Gehring, Ulrike
AU - Brunekreef, Bert
AU - Just, Allan C.
AU - Wright, Rosalind J.
AU - Peng, Cheng
AU - Gold, Diane R.
AU - Kloog, Itai
AU - DeMeo, Dawn L.
AU - Koppelman, Gerard H.
PY - 2019/5
Y1 - 2019/5
N2 - Background: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes.Objectives: We aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameterMethods: We meta-analyzed associations between exposure to PM10 (n=1,949) and PM2.5 (n=1,551) at maternal home addresses during pregnancy and newborn DNA methylation assessed by Illumina Infinium HumanMethylation450K BeadChip in nine European and American studies, with replication in 688 independent newborns and look-up analyses in 2,118 older children. We used two approaches, one focusing on single cytosine-phosphate-guanine (CpG) sites and another on differentially methylated regions (DMRs). We also related PM exposures to blood mRNA expression.Results: Six CpGs were significantly associated [false discovery rate (FDR)Conclusions: Several differentially methylated CpGs and DMRs associated with prenatal PM exposure were identified in newborns, with annotation to genes previously implicated in lung-related outcomes.
AB - Background: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes.Objectives: We aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameterMethods: We meta-analyzed associations between exposure to PM10 (n=1,949) and PM2.5 (n=1,551) at maternal home addresses during pregnancy and newborn DNA methylation assessed by Illumina Infinium HumanMethylation450K BeadChip in nine European and American studies, with replication in 688 independent newborns and look-up analyses in 2,118 older children. We used two approaches, one focusing on single cytosine-phosphate-guanine (CpG) sites and another on differentially methylated regions (DMRs). We also related PM exposures to blood mRNA expression.Results: Six CpGs were significantly associated [false discovery rate (FDR)Conclusions: Several differentially methylated CpGs and DMRs associated with prenatal PM exposure were identified in newborns, with annotation to genes previously implicated in lung-related outcomes.
KW - CHILDHOOD ASTHMA
KW - LUNG DEVELOPMENT
KW - GENE-EXPRESSION
KW - CORD BLOOD
KW - R-PACKAGE
KW - ASSOCIATION
KW - PREGNANCY
KW - EXPOSURE
KW - SUSCEPTIBILITY
KW - MATTER
U2 - 10.1289/EHP4522
DO - 10.1289/EHP4522
M3 - Article
VL - 127
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 5
M1 - 057012
ER -