Prenatal tobacco exposure influences cerebral oxygenation in preterm infants

Elise A. Verhagen*, Hendrik J. ter Horst, Elisabeth M. W. Kooi, Paul Keating, Paul P. van den Berg, Arend F. Bos

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Aim: Our aim was to determine the influence of prenatal tobacco exposure on regional cerebral tissue oxygen saturation (r(c)SO(2)) and fractional tissue oxygen extraction (FTOE) in preterm infants. We hypothesized that as a result of vasoconstriction caused by prenatal tobacco exposure r(c)SO(2) would be lower and FTOE would be higher during the first days after birth in infants exposed to tobacco during pregnancy.

Methods: Sixty preterms were included in this prospective, observational cohort study (median gestational age 29.9 weeks, range 26.0-31.8, median birth weight 1248 g, range 615-2250). Fourteen infants had been exposed to tobacco during pregnancy. All mothers smoked more than five cigarettes a day till delivery. We measured r(c)SO(2) and transcutaneous arterial oxygen saturation (tcSaO(2)) in all infants on days 1-5,8, and 15. FTOE was calculated: FTOE = (tcSaO(2) - r(c)SO(2))/tcSaO(2).

Results: In preterm infants exposed to tobacco during pregnancy, r(c)SO(2) was lower during days 1,2, and 8 after birth, median 73% versus 81%. 73% versus 80% and 71% versus 78% respectively. FTOE was higher during days 1 and 8 after birth, median 0.24 versus 0.15 and 0.26 versus 0.19 respectively. On the second day. FTOE tended to be higher. 0.18 versus 0.14.

Conclusions: During the first two days and day 8 after birth cerebral oxygen saturation is lower and oxygen extraction higher in preterm infants following prenatal tobacco exposure. Our data suggest that prenatal tobacco exposure may have an effect on cerebral oxygenation of the infant. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalEarly Human Development
Volume87
Issue number6
DOIs
Publication statusPublished - Jun-2011

Keywords

  • Preterm infants
  • Prenatal tobacco exposure
  • Cerebral oxygenation
  • Near-infrared spectroscopy
  • Fractional tissue oxygen extraction
  • NEAR-INFRARED SPECTROSCOPY
  • TISSUE OXYGENATION
  • SMOKING MOTHERS
  • NEWBORN-INFANTS
  • BLOOD-FLOW
  • CIGARETTE-SMOKING
  • EXTRACTION
  • PREGNANCY
  • NICOTINE
  • COTININE

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