Preoperative Chemotherapy with Cisplatin and Docetaxel Followed by Surgery and Clip-Oriented Postoperative Chemoradiation in Patients with Localized Gastric or Gastroesophageal Junction Adenocarcinoma: Results from a Phase II Feasibility Study

G. Spizzo*, D. Oefner, A. de Vries, P. Lukas, G. Steger, U. Pluschnig, J. Zacherl, J. Widder, A. Zabernigg, G. Gastl, G. Muehlmann

*Corresponding author for this work

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Abstract

We conducted a phase II feasibility study using preoperative chemotherapy with cisplatin and docetaxel followed by surgical resection and postoperative chemoradiation in patients with gastric or gastroesophageal cancer.

Preoperative chemotherapy (two or three cycles) consisted of 50 mg/m(2) docetaxel and 50 mg/m(2) cisplatin. Surgical resection was planned 4 weeks after the last chemotherapy cycle. Patients underwent postsurgical chemoradiation, receiving a total dose of 39.6 Gy and 5-fluorouracil (5-FU) continuous infusion (350 mg/m(2)/day). The primary end-points were feasibility, overall response rate and R0 resectability rate after preoperative chemotherapy. The secondary end-points were tolerability, treatment-associated complications, disease-free survival and overall survival.

Between 2002 and 2004, 15 patients were enrolled in this study. After neoadjuvant treatment, two patients (13%) experienced progressive disease, four patients (27%) showed partial remission and nine patients (60%) showed stable disease. In 11 patients (73%) R0 resectability could be achieved. Six of these patients (54%) were able to undergo postoperative chemoradiation. Notably, five (83%) of these patients were disease free and alive at median follow-up of 72 months. Chemotherapy-associated neutropaenia and neutropaenic fever, anastomotic dehiscence, pulmonary embolism and acute pancreatitis were observed.

The combination of preoperative chemotherapy and postoperative chemoradiation is feasible in a significant subset of gastric cancer patients.

Original languageEnglish
Pages (from-to)677-683
Number of pages7
JournalAnnals of Surgical Oncology
Volume18
Issue number3
DOIs
Publication statusPublished - Mar-2011
Externally publishedYes

Keywords

  • COMBINATION CHEMOTHERAPY
  • ADJUVANT CHEMOTHERAPY
  • PLUS CISPLATIN
  • CANCER
  • FLUOROURACIL
  • TRIAL
  • CARCINOMA
  • STOMACH

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