PREPARATION, CHARACTERIZATION, AND PHARMACEUTICAL APPLICATION OF LINEAR DEXTRIN .3. DRUG-RELEASE FROM FATTY SUPPOSITORY BASES CONTAINING AMYLODEXTRIN

GHP TEWIERIK, AC EISSENS, CF LERK

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5 Citations (Scopus)

Abstract

Drug release from fatty suppository bases containing a solid dispersion of diazepam with amylodextrin or a complex of prednisolone with amylodextrin was analyzed in a flow-through model. Being present as a suspension in the fatty base, particles of complex or solid dispersion are transported to the lipid-water interface by sedimentation. After entering the aqueous phase they partially dissolve. The suppositories showed increased drug release compared with the corresponding suppositories containing drug only. Because of the partial solubility of amylodextrin, drug release was lower than the release from drug-cyclodextrin complexes. Use of the soluble fraction of amylodextrin for both the solid dispersion and the complex further enhanced drug release, but it was still below that of drug-cyclodextrin complexes.

Original languageEnglish
Pages (from-to)108-110
Number of pages3
JournalPharmaceutical Research
Volume11
Issue number1
Publication statusPublished - Jan-1994

Keywords

  • AMYLODEXTRIN
  • COMPLEX
  • RELEASE MECHANISM
  • SOLID DISPERSION
  • SOLUBILITY
  • SUPPOSITORY
  • CYCLODEXTRINS

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