PREPARATION, CHARACTERIZATION, AND PHARMACEUTICAL APPLICATION OF LINEAR DEXTRINS .2. COMPLEXATION AND DISPERSION OF DRUGS WITH AMYLODEXTRIN BY FREEZE-DRYING AND KNEADING

GHPT WIERIK, AC EISSENS, AC BESEMER, CF LERK

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Abstract

The ability of amylodextrin (a linear dextrin) to act as a complexing agent or as a carrier for solid dispersion was evaluated. Blends of amylodextrin with diazepam or prednisolone were freeze-dried and kneaded at elevated temperatures, respectively. The products were analyzed by DSC, X-ray diffractometry, and FTIR spectroscopy. Complex formation with amylodextrin by freeze-drying was found not to occur for diazepam but for prednisolone at a molar ratio of 1 to 1. The freeze-dried product of diazepam with amylodextrin proved to be a solid dispersion. Solid dispersions were formed by both wet (with ethanol) and dry kneading at elevated temperatures of low-melting drugs such as lidocain, diazepam, and methyl-PABA with amylodextrin. No solid dispersions were obtained for high-melting drugs such as prednisolone and salicylic acid. The results point to the formation of solid dispersions by a melting mechanism during the process of kneading at elevated temperatures of low-melting drugs with amylodextrin.

Original languageEnglish
Pages (from-to)1280-1284
Number of pages5
JournalPharmaceutical Research
Volume10
Issue number9
Publication statusPublished - Sep-1993

Keywords

  • AMYLODEXTRIN
  • COMPLEXATION
  • SOLID DISPERSION
  • FREEZE-DRYING
  • KNEADING
  • STRUCTURAL CHARACTERIZATION
  • CYCLODEXTRINS

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