Prevalence and characteristics of noncompliant behaviour and its risk factors in kidney transplant recipients

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Abstract

Noncompliance with therapy is one possible explanation for the observation that long-term graft survival is not sufficiently improved by the development in immunosuppression. The aim of the study was to explore the prevalence, characteristics and risk factors of noncompliance with immunosuppression. A total of 161 adult kidney transplant recipients were inter-viewed about their self-rated health, social support, education, stress from adverse effects and compliance with the immunosuppression. The prevalence of subclinical noncompliance was 54%. Noncompliant patients declared significantly worse self-rated health, less satisfaction with social support and higher stress from adverse effects. Male gender (OR 7.5, CI 2.4-23.39), high stress from adverse effects (OR 12.27, CI 2.44-61.88), fair self-rated health (OR 4.45, CI 1.04-19.55) and fair satisfaction with social support (OR 4.55, CI 1.08-19.24) were predictors of noncompliance. Standardized detection methods should be developed with the aim of identifying patients who are at risk of noncompliance in order to prevent graft loss.

Original languageEnglish
Pages (from-to)1072-1078
Number of pages7
JournalTransplant International
Volume18
Issue number9
DOIs
Publication statusPublished - Sep-2005

Keywords

  • adverse effects
  • compliance immunosuppression
  • self-rated health
  • transplantation
  • QUALITY-OF-LIFE
  • LATE ACUTE REJECTION
  • RENAL-TRANSPLANT
  • IMMUNOSUPPRESSIVE THERAPY
  • MEDICATION NONCOMPLIANCE
  • ORGAN TRANSPLANT
  • PATIENT
  • DETERMINANTS
  • MULTICENTER
  • EXPERIENCE

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