TY - JOUR
T1 - Preventing preterm birth with progesterone
T2 - costs and effects of screening low risk women with a singleton pregnancy for short cervical length, the Triple P study
AU - van Os, Melanie A.
AU - van der Ven, Jeanine A.
AU - Kleinrouweler, C. Emily
AU - Pajkrt, Eva
AU - de Miranda, Esteriek
AU - van Wassenaer, Aleid
AU - Porath, Martina
AU - Bossuyt, Patrick M.
AU - Bloemenkamp, Kitty W. M.
AU - Willekes, Christine
AU - Woiski, Mallory
AU - Oudijk, Martijn A.
AU - Bilardo, Katia M.
AU - Sikkema, Marko J.
AU - Duvekot, Johannes J.
AU - Veersema, Diederik
AU - Laudy, Jacqueline
AU - Kuiper, Petra
AU - de Groot, Christianne J. M.
AU - Mol, Ben Willem J.
AU - Haak, Monique C.
PY - 2011/10/24
Y1 - 2011/10/24
N2 - Background: Women with a short cervical length in mid-trimester pregnancy have a higher risk of preterm birth and therefore a higher rate of neonatal mortality and morbidity. Progesterone can potentially decrease the number of preterm births and lower neonatal mortality and morbidity. Previous studies showed good results of progesterone in women with either a history of preterm birth or a short cervix. However, it is unknown whether screening for a short cervix and subsequent treatment in mid trimester pregnancy is effective in low risk women.Methods/Design: We plan a combined screen and treat study among women with a singleton pregnancy without a previous preterm birth. In these women, we will measure cervical length at the standard anomaly scan performed between 18 and 22 weeks. Women with cervical lengthDiscussion: This study will provide evidence for the usefulness and cost-effectiveness of screening for short cervical length at the 18-22 weeks and subsequent progesterone treatment among low risk women.
AB - Background: Women with a short cervical length in mid-trimester pregnancy have a higher risk of preterm birth and therefore a higher rate of neonatal mortality and morbidity. Progesterone can potentially decrease the number of preterm births and lower neonatal mortality and morbidity. Previous studies showed good results of progesterone in women with either a history of preterm birth or a short cervix. However, it is unknown whether screening for a short cervix and subsequent treatment in mid trimester pregnancy is effective in low risk women.Methods/Design: We plan a combined screen and treat study among women with a singleton pregnancy without a previous preterm birth. In these women, we will measure cervical length at the standard anomaly scan performed between 18 and 22 weeks. Women with cervical lengthDiscussion: This study will provide evidence for the usefulness and cost-effectiveness of screening for short cervical length at the 18-22 weeks and subsequent progesterone treatment among low risk women.
KW - CONTROLLED-TRIAL
KW - DELIVERY
KW - PREDICTION
U2 - 10.1186/1471-2393-11-77
DO - 10.1186/1471-2393-11-77
M3 - Article
SN - 1471-2393
VL - 11
JO - BMC Pregnancy and Childbirth
JF - BMC Pregnancy and Childbirth
M1 - 77
ER -