Preventing preterm birth with progesterone: costs and effects of screening low risk women with a singleton pregnancy for short cervical length, the Triple P study

Melanie A. van Os*, Jeanine A. van der Ven, C. Emily Kleinrouweler, Eva Pajkrt, Esteriek de Miranda, Aleid van Wassenaer, Martina Porath, Patrick M. Bossuyt, Kitty W. M. Bloemenkamp, Christine Willekes, Mallory Woiski, Martijn A. Oudijk, Katia M. Bilardo, Marko J. Sikkema, Johannes J. Duvekot, Diederik Veersema, Jacqueline Laudy, Petra Kuiper, Christianne J. M. de Groot, Ben Willem J. MolMonique C. Haak

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background: Women with a short cervical length in mid-trimester pregnancy have a higher risk of preterm birth and therefore a higher rate of neonatal mortality and morbidity. Progesterone can potentially decrease the number of preterm births and lower neonatal mortality and morbidity. Previous studies showed good results of progesterone in women with either a history of preterm birth or a short cervix. However, it is unknown whether screening for a short cervix and subsequent treatment in mid trimester pregnancy is effective in low risk women.

Methods/Design: We plan a combined screen and treat study among women with a singleton pregnancy without a previous preterm birth. In these women, we will measure cervical length at the standard anomaly scan performed between 18 and 22 weeks. Women with cervical length

Discussion: This study will provide evidence for the usefulness and cost-effectiveness of screening for short cervical length at the 18-22 weeks and subsequent progesterone treatment among low risk women.

Original languageEnglish
Article number77
Number of pages5
JournalBMC Pregnancy and Childbirth
Volume11
DOIs
Publication statusPublished - 24-Oct-2011

Keywords

  • CONTROLLED-TRIAL
  • DELIVERY
  • PREDICTION

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