Prevention of diabetes-associated fibrosis: Strategies in FcRn-targeted nanosystems for oral drug delivery

Cláudia Azevedo, Soraia Pinto, Sopisa Benjakul, Jeannette Nilsen, Hélder A. Santos, Giovanni Traverso, Jan Terje Andersen*, Bruno Sarmento*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

Diabetes mellitus is a chronic disease with an elevated risk of micro- and macrovascular complications, such as fibrosis. To prevent diabetes-associated fibrosis, the symptomatology of diabetes must be controlled, which is commonly done by subcutaneous injection of antidiabetic peptides. To minimize the pain and distress associated with such injections, there is an urgent need for non-invasive oral transmucosal drug delivery strategies. However, orally administered peptide-based drugs are exposed to harsh conditions in the gastrointestinal tract and poorly cross the selective intestinal epithelium. Thus, targeting of drugs to receptors expressed in epithelial cells, such as the neonatal Fc receptor (FcRn), may therefore enhance uptake and transport through mucosal barriers. This review compiles how in-depth studies of FcRn biology and engineering of receptor-binding molecules may pave the way for design of new classes of FcRn-targeted nanosystems. Tailored strategies may open new avenues for oral drug delivery and provide better treatment options for diabetes and, consequently, fibrosis prevention.
Original languageEnglish
Article number113778
Number of pages19
JournalAdvanced Drug Delivery Reviews
Volume175
DOIs
Publication statusPublished - Aug-2021
Externally publishedYes

Keywords

  • 317 Pharmacy
  • Antidiabetic peptides
  • FcRn
  • IgG
  • Albumin
  • Intestinal epithelium
  • Transcytosis
  • Half-life
  • Nanoparticles
  • Active targeting
  • Transgenic Mouse Model
  • I-RELATED RECEPTOR
  • PH-DEPENDENT BINDING
  • FAMILIAL HYPERCATABOLIC HYPOPROTEINEMIA
  • AMINO-ACID-RESIDUES
  • HUMAN SERUM-ALBUMIN
  • EXTENDED HALF-LIFE
  • CRYSTAL-STRUCTURE
  • IMMUNOGLOBULIN-G
  • HUMAN-IGG
  • TRANSGENIC MICE

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