Principles of ubiquitin and SUMO modifications in DNA repair

Steven Bergink; Stefan Jentsch

doi:10.1038/nature07963

Principles of ubiquitin and SUMO modifications in DNA repair

Steven Bergink, Stefan Jentsch^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

440 Citations (Scopus)

Abstract

With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a much broader significance than had previously been assumed. Now, two decades later, ubiquitin and its cousin SUMO are implicated in a range of human diseases, including breast cancer and Fanconi anaemia, giving fresh momentum to studies focused on the relationships between ubiquitin, SUMO and DNA-repair pathways.

Original language	English
Pages (from-to)	461-467
Number of pages	7
Journal	Nature
Volume	458
Issue number	7237
DOIs	https://doi.org/10.1038/nature07963
Publication status	Published - 26-Mar-2009

Keywords

NUCLEOTIDE EXCISION-REPAIR
FANCONI-ANEMIA PATHWAY
GROUP-C PROTEIN
CONJUGATING ENZYME
DAMAGE RESPONSE
INDUCED UBIQUITYLATION
BINDING PROTEINS
REPLICATION FORK
TOPOISOMERASE-II
S-PHASE

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Cite this

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title = "Principles of ubiquitin and SUMO modifications in DNA repair",

abstract = "With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a much broader significance than had previously been assumed. Now, two decades later, ubiquitin and its cousin SUMO are implicated in a range of human diseases, including breast cancer and Fanconi anaemia, giving fresh momentum to studies focused on the relationships between ubiquitin, SUMO and DNA-repair pathways.",

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author = "Steven Bergink and Stefan Jentsch",

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T1 - Principles of ubiquitin and SUMO modifications in DNA repair

AU - Bergink, Steven

AU - Jentsch, Stefan

PY - 2009/3/26

Y1 - 2009/3/26

N2 - With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a much broader significance than had previously been assumed. Now, two decades later, ubiquitin and its cousin SUMO are implicated in a range of human diseases, including breast cancer and Fanconi anaemia, giving fresh momentum to studies focused on the relationships between ubiquitin, SUMO and DNA-repair pathways.

AB - With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a much broader significance than had previously been assumed. Now, two decades later, ubiquitin and its cousin SUMO are implicated in a range of human diseases, including breast cancer and Fanconi anaemia, giving fresh momentum to studies focused on the relationships between ubiquitin, SUMO and DNA-repair pathways.

KW - NUCLEOTIDE EXCISION-REPAIR

KW - FANCONI-ANEMIA PATHWAY

KW - GROUP-C PROTEIN

KW - CONJUGATING ENZYME

KW - DAMAGE RESPONSE

KW - INDUCED UBIQUITYLATION

KW - BINDING PROTEINS

KW - REPLICATION FORK

KW - TOPOISOMERASE-II

KW - S-PHASE

U2 - 10.1038/nature07963

DO - 10.1038/nature07963

M3 - Review article

VL - 458

SP - 461

EP - 467

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7237

ER -