Principles of ubiquitin and SUMO modifications in DNA repair

Steven Bergink, Stefan Jentsch*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

440 Citations (Scopus)

Abstract

With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a much broader significance than had previously been assumed. Now, two decades later, ubiquitin and its cousin SUMO are implicated in a range of human diseases, including breast cancer and Fanconi anaemia, giving fresh momentum to studies focused on the relationships between ubiquitin, SUMO and DNA-repair pathways.

Original languageEnglish
Pages (from-to)461-467
Number of pages7
JournalNature
Volume458
Issue number7237
DOIs
Publication statusPublished - 26-Mar-2009

Keywords

  • NUCLEOTIDE EXCISION-REPAIR
  • FANCONI-ANEMIA PATHWAY
  • GROUP-C PROTEIN
  • CONJUGATING ENZYME
  • DAMAGE RESPONSE
  • INDUCED UBIQUITYLATION
  • BINDING PROTEINS
  • REPLICATION FORK
  • TOPOISOMERASE-II
  • S-PHASE

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