Pro- and anti-fibrotic agents in liver fibrosis: Perspective from an ex vivo model of liver fibrosis

S. Suriguga

Research output: ThesisThesis fully internal (DIV)

456 Downloads (Pure)

Abstract

This thesis provides new insight into the association of the gut-liver axis with liver fibrosis and demonstrates that the development of small molecule inhibitors of the TGF-β signaling pathway is an encouraging strategy to extenuate liver fibrosis. In addition, modulating oxidative stress, another pro-fibrogenic signal, might provide a bright future for combatting liver fibrosis. Moreover, we exhibited here a promising ex-vivo tool, the precision-cut liver slices, for its application in exploring mechanism of liver fibrosis as well as in anti-fibrotic drug discovery in a clinically relevant situation, thereby reducing and refining animal experiments.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Groningen
Supervisors/Advisors
  • Olinga, Peter, Supervisor
  • Groothuis, Geny, Supervisor
Award date8-Apr-2019
Print ISBNs978-94-034-1551-2
Electronic ISBNs978-94-034-1550-5
Publication statusPublished - 2019

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