Pro- and anti-fibrotic agents in liver fibrosis: Perspective from an ex vivo model of liver fibrosis

S. Suriguga

Pro- and anti-fibrotic agents in liver fibrosis: Perspective from an ex vivo model of liver fibrosis

S. Suriguga

Pharmaceutical Technology and Biopharmacy

Research output: Thesis › Thesis fully internal (DIV)

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Abstract

This thesis provides new insight into the association of the gut-liver axis with liver fibrosis and demonstrates that the development of small molecule inhibitors of the TGF-β signaling pathway is an encouraging strategy to extenuate liver fibrosis. In addition, modulating oxidative stress, another pro-fibrogenic signal, might provide a bright future for combatting liver fibrosis. Moreover, we exhibited here a promising ex-vivo tool, the precision-cut liver slices, for its application in exploring mechanism of liver fibrosis as well as in anti-fibrotic drug discovery in a clinically relevant situation, thereby reducing and refining animal experiments.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Groningen
Supervisors/Advisors	Olinga, Peter, Supervisor Groothuis, Genoveva, Supervisor
Award date	8-Apr-2019
Print ISBNs	978-94-034-1551-2
Electronic ISBNs	978-94-034-1550-5
Publication status	Published - 2019

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Title and contentsFinal publisher's version, 288 KB
Chapter 1Final publisher's version, 7.66 MB
Chapter 2Final publisher's version, 12.6 MB
Chapter 3Final publisher's version, 58.4 MB
Chapter 4Final publisher's version, 2.88 MB
Chapter 5Final publisher's version, 3.49 MB
Chapter 6Final publisher's version, 3.16 MB
Chapter 7Final publisher's version, 1.48 MB
Chapter 8Final publisher's version, 173 KB
AppendixFinal publisher's version, 1.37 MB
Complete thesisFinal publisher's version, 75.8 MB
PropositionsFinal publisher's version, 29.9 KB

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title = "Pro- and anti-fibrotic agents in liver fibrosis: Perspective from an ex vivo model of liver fibrosis",

abstract = "This thesis provides new insight into the association of the gut-liver axis with liver fibrosis and demonstrates that the development of small molecule inhibitors of the TGF-β signaling pathway is an encouraging strategy to extenuate liver fibrosis. In addition, modulating oxidative stress, another pro-fibrogenic signal, might provide a bright future for combatting liver fibrosis. Moreover, we exhibited here a promising ex-vivo tool, the precision-cut liver slices, for its application in exploring mechanism of liver fibrosis as well as in anti-fibrotic drug discovery in a clinically relevant situation, thereby reducing and refining animal experiments.",

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year = "2019",

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TY - BOOK

T1 - Pro- and anti-fibrotic agents in liver fibrosis

T2 - Perspective from an ex vivo model of liver fibrosis

AU - Suriguga, S.

PY - 2019

Y1 - 2019

N2 - This thesis provides new insight into the association of the gut-liver axis with liver fibrosis and demonstrates that the development of small molecule inhibitors of the TGF-β signaling pathway is an encouraging strategy to extenuate liver fibrosis. In addition, modulating oxidative stress, another pro-fibrogenic signal, might provide a bright future for combatting liver fibrosis. Moreover, we exhibited here a promising ex-vivo tool, the precision-cut liver slices, for its application in exploring mechanism of liver fibrosis as well as in anti-fibrotic drug discovery in a clinically relevant situation, thereby reducing and refining animal experiments.

AB - This thesis provides new insight into the association of the gut-liver axis with liver fibrosis and demonstrates that the development of small molecule inhibitors of the TGF-β signaling pathway is an encouraging strategy to extenuate liver fibrosis. In addition, modulating oxidative stress, another pro-fibrogenic signal, might provide a bright future for combatting liver fibrosis. Moreover, we exhibited here a promising ex-vivo tool, the precision-cut liver slices, for its application in exploring mechanism of liver fibrosis as well as in anti-fibrotic drug discovery in a clinically relevant situation, thereby reducing and refining animal experiments.

M3 - Thesis fully internal (DIV)

SN - 978-94-034-1551-2

ER -

Pro- and anti-fibrotic agents in liver fibrosis: Perspective from an ex vivo model of liver fibrosis

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