Prognostic value of 11C-methionine volume-based PET parameters in IDH wild type glioblastoma

Bart R J van Dijken*, Alfred O Ankrah, Gilles N Stormezand, Rudi A J O Dierckx, Peter Jan van Laar, Anouk van der Hoorn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
75 Downloads (Pure)

Abstract

Purpose

C-11-Methionine (C-11-MET) PET prognostication of isocitrate dehydrogenase (IDH) wild type glioblastomas is inadequate as conventional parameters such as standardized uptake value (SUV) do not adequately reflect tumor heterogeneity. We retrospectively evaluated whether volume-based parameters such as metabolic tumor volume (MTV) and total lesion methionine metabolism (TLMM) outperformed SUV for survival correlation in patients with IDH wild type glioblastomas.

Methods

Thirteen IDH wild type glioblastoma patients underwent preoperative C-11-MET PET. Both SUV-based parameters and volume-based parameters were calculated for each lesion. Kaplan-Meier curves with log-rank testing and Cox regression analysis were used for correlation between PET parameters and overall survival.

Results

Median overall survival for the entire cohort was 393 days. MTV (HR 1.136, p = 0.007) and TLMM (HR 1.022, p = 0.030) were inversely correlated with overall survival. SUV-based C-11-MET PET parameters did not show a correlation with survival. In a paired analysis with other clinical parameters including age and radiotherapy dose, MTV and TLMM were found to be independent factors.

Conclusions

MTV and TLMM, and not SUV, significantly correlate with overall survival in patients with IDH wild type glioblastomas. The incorporation of volume-based C-11-MET PET parameters may lead to a better outcome prediction for this heterogeneous patient population.

Original languageEnglish
Article number0264387
Number of pages8
JournalPLoS ONE
Volume17
Issue number2
DOIs
Publication statusPublished - 25-Feb-2022

Keywords

  • Adult
  • Aged
  • Disease-Free Survival
  • Female
  • Glioblastoma/diagnostic imaging
  • Humans
  • Isocitrate Dehydrogenase/metabolism
  • Male
  • Methionine/administration & dosage
  • Middle Aged
  • Neoplasm Proteins/metabolism
  • Positron Emission Tomography Computed Tomography
  • Survival Rate
  • Tumor Burden

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