Programming effects of an early-life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet

Onne A H O Ronda, Bert J M van de Heijning, Alain de Bruin, Angelika Jurdzinski, Folkert Kuipers, Henkjan J Verkade*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
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Abstract

Breastfeeding is associated with a lower risk of developing obesity during childhood and adulthood compared to feeding infant milk formula (IMF). Previous studies have shown that an experimental IMF (eIMF; comprising Nuturis®), programmed mouse pups for a lower body weight and fat mass gain in adulthood when challenged with a high-fat diet (HFD), compared to a control IMF (cIMF). Nuturis has a lipid composition and structure more similar to breastmilk. Here, the long-term effects were tested of a similar eIMF, but with an adapted lipid composition, and a cIMF, on body weight, glucose homeostasis, liver and adipose tissue. Nutrient composition was similar for the eIMF and cIMF; the lipid fractions comprised ~50% milkfat. C57BL/6JOlaHsd mice were fed cIMF or eIMF from postnatal (PN) day 16-42 followed by a HFD until PN168. Feeding eIMF versus cIMF in early life resulted in a lower body weight (-9%) and body fat deposition (-14%) in adulthood (PN105). The effect appeared transient, as from PN126 onward, after 12 weeks HFD, eIMF-fed mice caught up on controls and body and fat weights became comparable between groups. Glucose and energy metabolism were similar between groups. At dissection (PN168), eIMF-fed mice showed larger (+27%) epididymal fat depots and a lower (-26%) liver weight without clear morphological aberrations. Our data suggest the size and coating but not the lipid composition of IMF fat globules underlies the programming effect observed. Prolonged exposure to a HFD challenge partly overrules the programming effect of early diet.

Original languageEnglish
Pages (from-to)1321-1328
Number of pages8
JournalBritish Journal of Nutrition
Volume122
Issue number12
Early online date23-Aug-2019
DOIs
Publication statusPublished - 28-Dec-2019

Keywords

  • Metabolic programming
  • Infant nutrition
  • Dietary lipids
  • Lipid structure
  • Milk fat globule membrane
  • Obesity prevention
  • Animal models
  • BREAST-MILK
  • SIZE
  • ABSORPTION
  • FORMULA
  • TISSUE
  • ACID
  • ACCUMULATION
  • CHOLESTEROL
  • LIPOLYSIS
  • DROPLETS

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