Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation

VM Heine*, S Maslam, M Joels, PJ Lucassen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

254 Citations (Scopus)

Abstract

Neurogenesis and apoptosis in the hippocampal dentate gyrus (DG) occur during development and adulthood. However, little is known about how these two processes relate to each other during aging. In this study, we examined apoptosis, proliferation, migration, and survival of newborn cells in the young (2 weeks), young-adult (6 weeks), middle-aged (12 months), and old (24 months) rat DG. We also measured dentate volume and cell numbers, along with basal corticosterone and stress response parameters. We show that new cell proliferation and apoptosis slow down profoundly over this time period. Moreover, migration and differentiation into a neuronal or glial phenotype was strongly reduced from 6 weeks of age onwards; it was hardly present in middle-aged and old rats as confirmed by confocal analysis. Surprisingly, we found no correlation between cell birth and corticosterone levels or stress response parameters in any age group. (C) 2003 Elsevier Science Inc. All rights reserved.

Original languageEnglish
Pages (from-to)361-375
Number of pages15
JournalNeurobiology of Aging
Volume25
Issue number3
DOIs
Publication statusPublished - Mar-2004
Externally publishedYes

Keywords

  • aging
  • neurogenesis
  • apoptosis
  • migration
  • stress
  • corticosterone
  • rat
  • wistar
  • hippocampus
  • FIBROBLAST-GROWTH-FACTOR
  • MONOCLONAL-ANTIBODY KI-67
  • BROWN-NORWAY RAT
  • HIPPOCAMPAL NEUROGENESIS
  • ADULT NEUROGENESIS
  • GRANULE CELLS
  • SYNAPTIC TRANSMISSION
  • PSYCHOSOCIAL STRESS
  • ALZHEIMER-DISEASE
  • NUCLEAR ANTIGEN

Cite this