Promiscuous Catalysis of Asymmetric Michael-Type Additions of Linear Aldehydes to beta-Nitrostyrene by the Proline-Based Enzyme 4-Oxalocrotonate Tautomerase

Yufeng Miao, Edzard M. Geertsema, Pieter G. Tepper, Ellen Zandvoort, Gerrit J. Poelarends*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)
Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalChemBioChem
Volume14
Issue number2
DOIs
Publication statusPublished - 21-Jan-2013

Keywords

  • biocatalysis
  • catalytic promiscuity
  • Michael addition
  • nitroaldehydes
  • tautomerases
  • DIPHENYLPROLINOL SILYL ETHER
  • MIGRATION INHIBITORY FACTOR
  • CARBON BOND FORMATION
  • ENANTIOSELECTIVE MICHAEL
  • 1,4-ADDITION REACTIONS
  • EFFICIENT
  • WATER
  • ORGANOCATALYSTS
  • NITROOLEFINS
  • ACETALDEHYDE

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