Prospective analysis of lipid profiles in persons with a spinal cord injury during and 1 year after inpatient rehabilitation

Sonja de Groot; Annet J Dallmeijer; Marcel W Post; Edmond L Angenot; Rita J van den Berg-Emons; Luc H.  van der Woude

doi:10.1016/j.apmr.2007.11.023

Prospective analysis of lipid profiles in persons with a spinal cord injury during and 1 year after inpatient rehabilitation

Sonja de Groot, Annet J Dallmeijer, Marcel W Post, Edmond L Angenot, Rita J van den Berg-Emons, Luc H. van der Woude

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Abstract

OBJECTIVES: To investigate the course of lipid profiles during and 1 year after inpatient rehabilitation of persons with spinal cord injury, and to determine which personal, lesion, and lifestyle characteristics influence the changes in lipid profiles over time and among subjects.

DESIGN: Multilevel regression analysis of measurement points during and after rehabilitation.

SETTING: Eight rehabilitation centers in The Netherlands.

PARTICIPANTS: People with complete and incomplete paraplegia and tetraplegia (N=180).

INTERVENTIONS: Not applicable.

MAIN OUTCOME MEASURES: Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG), and the TC/HDL ratio.

RESULTS: We found a significant decrease in TG and TC/HDL during inpatient rehabilitation and a significant increase in HDL during and after inpatient rehabilitation. TC and LDL, however, showed unfavorable increases after clinical discharge. The changes in HDL and LDL over time differed between lesion groups. An increase in the body mass index (BMI) led to an unfavorable change in all lipid profiles. Older participants showed higher TC, LDL, and HDL concentrations. Women and participants who consumed some alcohol, or who were more active 1 year after discharge, had more favorable HDL levels.

CONCLUSIONS: Lipid profiles improved during inpatient rehabilitation but deteriorated somewhat after clinical discharge. Controlling one's BMI seems important in diminishing the risk for unfavorable lipid profiles.

Original language	English
Pages (from-to)	531-7
Number of pages	7
Journal	Archives of Physical Medicine and Rehabilitation
Volume	89
Issue number	3
DOIs	https://doi.org/10.1016/j.apmr.2007.11.023
Publication status	Published - Mar-2008
Externally published	Yes

Keywords

Adolescent
Adult
Age Factors
Aged
Body Mass Index
Cholesterol, HDL
Cohort Studies
Humans
Injury Severity Score
Inpatients
Life Style
Lipids
Male
Middle Aged
Multicenter Studies as Topic
Multivariate Analysis
Paraplegia
Physical Therapy Modalities
Predictive Value of Tests
Probability
Prospective Studies
Quadriplegia
Regression Analysis
Rehabilitation Centers
Spinal Cord Injuries
Time Factors
Treatment Outcome

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title = "Prospective analysis of lipid profiles in persons with a spinal cord injury during and 1 year after inpatient rehabilitation",

abstract = "OBJECTIVES: To investigate the course of lipid profiles during and 1 year after inpatient rehabilitation of persons with spinal cord injury, and to determine which personal, lesion, and lifestyle characteristics influence the changes in lipid profiles over time and among subjects.DESIGN: Multilevel regression analysis of measurement points during and after rehabilitation.SETTING: Eight rehabilitation centers in The Netherlands.PARTICIPANTS: People with complete and incomplete paraplegia and tetraplegia (N=180).INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG), and the TC/HDL ratio.RESULTS: We found a significant decrease in TG and TC/HDL during inpatient rehabilitation and a significant increase in HDL during and after inpatient rehabilitation. TC and LDL, however, showed unfavorable increases after clinical discharge. The changes in HDL and LDL over time differed between lesion groups. An increase in the body mass index (BMI) led to an unfavorable change in all lipid profiles. Older participants showed higher TC, LDL, and HDL concentrations. Women and participants who consumed some alcohol, or who were more active 1 year after discharge, had more favorable HDL levels.CONCLUSIONS: Lipid profiles improved during inpatient rehabilitation but deteriorated somewhat after clinical discharge. Controlling one's BMI seems important in diminishing the risk for unfavorable lipid profiles.",

keywords = "Adolescent, Adult, Age Factors, Aged, Body Mass Index, Cholesterol, HDL, Cohort Studies, Humans, Injury Severity Score, Inpatients, Life Style, Lipids, Male, Middle Aged, Multicenter Studies as Topic, Multivariate Analysis, Paraplegia, Physical Therapy Modalities, Predictive Value of Tests, Probability, Prospective Studies, Quadriplegia, Regression Analysis, Rehabilitation Centers, Spinal Cord Injuries, Time Factors, Treatment Outcome",

author = "{de Groot}, Sonja and Dallmeijer, {Annet J} and Post, {Marcel W} and Angenot, {Edmond L} and {van den Berg-Emons}, {Rita J} and {van der Woude}, {Luc H.}",

year = "2008",

month = mar,

doi = "10.1016/j.apmr.2007.11.023",

language = "English",

volume = "89",

pages = "531--7",

journal = "Archives of Physical Medicine and Rehabilitation",

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number = "3",

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TY - JOUR

T1 - Prospective analysis of lipid profiles in persons with a spinal cord injury during and 1 year after inpatient rehabilitation

AU - de Groot, Sonja

AU - Dallmeijer, Annet J

AU - Post, Marcel W

AU - Angenot, Edmond L

AU - van den Berg-Emons, Rita J

AU - van der Woude, Luc H.

PY - 2008/3

Y1 - 2008/3

N2 - OBJECTIVES: To investigate the course of lipid profiles during and 1 year after inpatient rehabilitation of persons with spinal cord injury, and to determine which personal, lesion, and lifestyle characteristics influence the changes in lipid profiles over time and among subjects.DESIGN: Multilevel regression analysis of measurement points during and after rehabilitation.SETTING: Eight rehabilitation centers in The Netherlands.PARTICIPANTS: People with complete and incomplete paraplegia and tetraplegia (N=180).INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG), and the TC/HDL ratio.RESULTS: We found a significant decrease in TG and TC/HDL during inpatient rehabilitation and a significant increase in HDL during and after inpatient rehabilitation. TC and LDL, however, showed unfavorable increases after clinical discharge. The changes in HDL and LDL over time differed between lesion groups. An increase in the body mass index (BMI) led to an unfavorable change in all lipid profiles. Older participants showed higher TC, LDL, and HDL concentrations. Women and participants who consumed some alcohol, or who were more active 1 year after discharge, had more favorable HDL levels.CONCLUSIONS: Lipid profiles improved during inpatient rehabilitation but deteriorated somewhat after clinical discharge. Controlling one's BMI seems important in diminishing the risk for unfavorable lipid profiles.

AB - OBJECTIVES: To investigate the course of lipid profiles during and 1 year after inpatient rehabilitation of persons with spinal cord injury, and to determine which personal, lesion, and lifestyle characteristics influence the changes in lipid profiles over time and among subjects.DESIGN: Multilevel regression analysis of measurement points during and after rehabilitation.SETTING: Eight rehabilitation centers in The Netherlands.PARTICIPANTS: People with complete and incomplete paraplegia and tetraplegia (N=180).INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG), and the TC/HDL ratio.RESULTS: We found a significant decrease in TG and TC/HDL during inpatient rehabilitation and a significant increase in HDL during and after inpatient rehabilitation. TC and LDL, however, showed unfavorable increases after clinical discharge. The changes in HDL and LDL over time differed between lesion groups. An increase in the body mass index (BMI) led to an unfavorable change in all lipid profiles. Older participants showed higher TC, LDL, and HDL concentrations. Women and participants who consumed some alcohol, or who were more active 1 year after discharge, had more favorable HDL levels.CONCLUSIONS: Lipid profiles improved during inpatient rehabilitation but deteriorated somewhat after clinical discharge. Controlling one's BMI seems important in diminishing the risk for unfavorable lipid profiles.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Aged

KW - Body Mass Index

KW - Cholesterol, HDL

KW - Cohort Studies

KW - Humans

KW - Injury Severity Score

KW - Inpatients

KW - Life Style

KW - Lipids

KW - Male

KW - Middle Aged

KW - Multicenter Studies as Topic

KW - Multivariate Analysis

KW - Paraplegia

KW - Physical Therapy Modalities

KW - Predictive Value of Tests

KW - Probability

KW - Prospective Studies

KW - Quadriplegia

KW - Regression Analysis

KW - Rehabilitation Centers

KW - Spinal Cord Injuries

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1016/j.apmr.2007.11.023

DO - 10.1016/j.apmr.2007.11.023

M3 - Article

C2 - 18295633

SN - 0003-9993

VL - 89

SP - 531

EP - 537

JO - Archives of Physical Medicine and Rehabilitation

JF - Archives of Physical Medicine and Rehabilitation

IS - 3

ER -

Prospective analysis of lipid profiles in persons with a spinal cord injury during and 1 year after inpatient rehabilitation

Abstract

Keywords

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