PROSTHETIC MICROVENOUS GRAFTING IN THE RAT FEMORAL VEIN

B VANDERLEI, PH ROBINSON, H. Bartels

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6 Citations (Scopus)

Abstract

Male Wistar rats were used to evaluate microvenous prosthetic grafting techniques and microvenous prostheses in the femoral vein. With the end-to-end technique to implant microvenous prostheses, there was extensive exposure of vessel wall collagen especially at the suture sites. Thrombus formation then led to complete occlusion in all but one of the 32 prostheses 60 min after implantation. However, with the sleeve anastomotic technique there was only minimal exposure of collagen and minimal thrombus accumulation. Fifty-nine of the 64 microvenous prostheses implanted with the sleeve technique were patent after 1 day, 1, 3, 6, and 12 weeks (patency rate 92%). All patent microvenous prostheses were completely covered by an endothelial layer after 3 weeks. It was concluded that the rat is an appropriate experimental laboratory animal for evaluating new grafting techniques with microvenous prostheses and that the sleeve anastomotic technique gives the highest patency rates with microvenous prostheses.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalLaboratory Animals
Volume27
Issue number1
Publication statusPublished - Jan-1993

Keywords

  • RAT
  • MICROVENOUS PROSTHESIS
  • MICROSURGERY
  • SLEEVE ANASTOMOTIC TECHNIQUE
  • POLYTETRAFLUOROETHYLENE PROSTHESES
  • VASCULAR GRAFTS
  • PATENCY
  • ARTERIAL

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