Prosthetic valves in adult patients with congenital heart disease: Rationale and design of the Dutch PROSTAVA study

H. G. Freling; Y. J. van Slooten; J. P. van Melle; B. J. M. Mulder; A. P. J. van Dijk; H. L. Hillege; M. C. Post; G. Tj Sieswerda; M. R. M. Jongbloed; T. P. Willems; P. G. Pieper; PROSTAVA Investigators

doi:10.1007/s12471-012-0308-4

Prosthetic valves in adult patients with congenital heart disease: Rationale and design of the Dutch PROSTAVA study

H. G. Freling, Y. J. van Slooten, J. P. van Melle, B. J. M. Mulder, A. P. J. van Dijk, H. L. Hillege, M. C. Post, G. Tj Sieswerda, M. R. M. Jongbloed, T. P. Willems, P. G. Pieper^*, PROSTAVA Investigators

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

Data on long-term complications in adult patients with congenital heart disease (ACHD) and a prosthetic valve are scarce. Moreover, the influence of prosthetic valves on quality of life (QoL) and functional outcome in ACHD patients with prosthetic valves has not been studied.

The primary objective of the PROSTAVA study is to investigate the relation between prosthetic valve characteristics (type, size and location) and functional outcome as well as QoL in ACHD patients. The secondary objectives are to investigate the prevalence and predictors of prosthesis-related complications including prosthesis-patient mismatch.

The PROSTAVA study, a multicentre cross-sectional observational study, will include approximately 550 ACHD patients with prosthetic valves. Primary outcome measures are maximum oxygen uptake during cardiopulmonary exercise testing and QoL. Secondary outcomes are the prevalence and incidence of valve-related complications including prosthesis-patient mismatch. Other evaluations are medical history, physical examination, echocardiography, MRI, rhythm monitoring and laboratory evaluation (including NT-proBNP).

Identification of the relation between prosthetic valve characteristics in ACHD patients on one hand and functional outcome, QoL, the prevalence and predictors of prosthesis-related complications on the other hand may influence the choice of valve prosthesis, the indication for more extensive surgery and the indication for re-operation.

Original language	English
Pages (from-to)	419-424
Number of pages	6
Journal	Netherlands Heart Journal
Volume	20
Issue number	10
DOIs	https://doi.org/10.1007/s12471-012-0308-4
Publication status	Published - Oct-2012

Keywords

Congenital heart disease
Prosthesis-patient mismatch
Prosthetic heart valve
Valvular heart disease
Functional outcome
Quality of life
QUALITY-OF-LIFE
MECHANICAL PROSTHESIS
REPLACEMENT
MISMATCH
PREGNANCY
CHILDREN
IMPACT
MORTALITY
POSITION
WOMEN

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Freling, H. G., van Slooten, Y. J., van Melle, J. P., Mulder, B. J. M., van Dijk, A. P. J., Hillege, H. L., Post, M. C., Sieswerda, G. T., Jongbloed, M. R. M., Willems, T. P., Pieper, P. G., & PROSTAVA Investigators (2012). Prosthetic valves in adult patients with congenital heart disease: Rationale and design of the Dutch PROSTAVA study. Netherlands Heart Journal, 20(10), 419-424. https://doi.org/10.1007/s12471-012-0308-4

@article{ef08f76a58cf48568854ff18c67f50d0,

title = "Prosthetic valves in adult patients with congenital heart disease: Rationale and design of the Dutch PROSTAVA study",

abstract = "Data on long-term complications in adult patients with congenital heart disease (ACHD) and a prosthetic valve are scarce. Moreover, the influence of prosthetic valves on quality of life (QoL) and functional outcome in ACHD patients with prosthetic valves has not been studied.The primary objective of the PROSTAVA study is to investigate the relation between prosthetic valve characteristics (type, size and location) and functional outcome as well as QoL in ACHD patients. The secondary objectives are to investigate the prevalence and predictors of prosthesis-related complications including prosthesis-patient mismatch.The PROSTAVA study, a multicentre cross-sectional observational study, will include approximately 550 ACHD patients with prosthetic valves. Primary outcome measures are maximum oxygen uptake during cardiopulmonary exercise testing and QoL. Secondary outcomes are the prevalence and incidence of valve-related complications including prosthesis-patient mismatch. Other evaluations are medical history, physical examination, echocardiography, MRI, rhythm monitoring and laboratory evaluation (including NT-proBNP).Identification of the relation between prosthetic valve characteristics in ACHD patients on one hand and functional outcome, QoL, the prevalence and predictors of prosthesis-related complications on the other hand may influence the choice of valve prosthesis, the indication for more extensive surgery and the indication for re-operation.",

keywords = "Congenital heart disease, Prosthesis-patient mismatch, Prosthetic heart valve, Valvular heart disease, Functional outcome, Quality of life, QUALITY-OF-LIFE, MECHANICAL PROSTHESIS, REPLACEMENT, MISMATCH, PREGNANCY, CHILDREN, IMPACT, MORTALITY, POSITION, WOMEN",

author = "Freling, {H. G.} and {van Slooten}, {Y. J.} and {van Melle}, {J. P.} and Mulder, {B. J. M.} and {van Dijk}, {A. P. J.} and Hillege, {H. L.} and Post, {M. C.} and Sieswerda, {G. Tj} and Jongbloed, {M. R. M.} and Willems, {T. P.} and Pieper, {P. G.} and {PROSTAVA Investigators}",

year = "2012",

month = oct,

doi = "10.1007/s12471-012-0308-4",

language = "English",

volume = "20",

pages = "419--424",

journal = "Netherlands Heart Journal",

issn = "1568-5888",

publisher = "Bohn, Stafleu, Van Loghum",

number = "10",

}

Freling, HG, van Slooten, YJ, van Melle, JP, Mulder, BJM, van Dijk, APJ, Hillege, HL, Post, MC, Sieswerda, GT, Jongbloed, MRM, Willems, TP, Pieper, PG & PROSTAVA Investigators 2012, 'Prosthetic valves in adult patients with congenital heart disease: Rationale and design of the Dutch PROSTAVA study', Netherlands Heart Journal, vol. 20, no. 10, pp. 419-424. https://doi.org/10.1007/s12471-012-0308-4

TY - JOUR

T1 - Prosthetic valves in adult patients with congenital heart disease

T2 - Rationale and design of the Dutch PROSTAVA study

AU - Freling, H. G.

AU - van Slooten, Y. J.

AU - van Melle, J. P.

AU - Mulder, B. J. M.

AU - van Dijk, A. P. J.

AU - Hillege, H. L.

AU - Post, M. C.

AU - Sieswerda, G. Tj

AU - Jongbloed, M. R. M.

AU - Willems, T. P.

AU - Pieper, P. G.

AU - PROSTAVA Investigators

PY - 2012/10

Y1 - 2012/10

N2 - Data on long-term complications in adult patients with congenital heart disease (ACHD) and a prosthetic valve are scarce. Moreover, the influence of prosthetic valves on quality of life (QoL) and functional outcome in ACHD patients with prosthetic valves has not been studied.The primary objective of the PROSTAVA study is to investigate the relation between prosthetic valve characteristics (type, size and location) and functional outcome as well as QoL in ACHD patients. The secondary objectives are to investigate the prevalence and predictors of prosthesis-related complications including prosthesis-patient mismatch.The PROSTAVA study, a multicentre cross-sectional observational study, will include approximately 550 ACHD patients with prosthetic valves. Primary outcome measures are maximum oxygen uptake during cardiopulmonary exercise testing and QoL. Secondary outcomes are the prevalence and incidence of valve-related complications including prosthesis-patient mismatch. Other evaluations are medical history, physical examination, echocardiography, MRI, rhythm monitoring and laboratory evaluation (including NT-proBNP).Identification of the relation between prosthetic valve characteristics in ACHD patients on one hand and functional outcome, QoL, the prevalence and predictors of prosthesis-related complications on the other hand may influence the choice of valve prosthesis, the indication for more extensive surgery and the indication for re-operation.

AB - Data on long-term complications in adult patients with congenital heart disease (ACHD) and a prosthetic valve are scarce. Moreover, the influence of prosthetic valves on quality of life (QoL) and functional outcome in ACHD patients with prosthetic valves has not been studied.The primary objective of the PROSTAVA study is to investigate the relation between prosthetic valve characteristics (type, size and location) and functional outcome as well as QoL in ACHD patients. The secondary objectives are to investigate the prevalence and predictors of prosthesis-related complications including prosthesis-patient mismatch.The PROSTAVA study, a multicentre cross-sectional observational study, will include approximately 550 ACHD patients with prosthetic valves. Primary outcome measures are maximum oxygen uptake during cardiopulmonary exercise testing and QoL. Secondary outcomes are the prevalence and incidence of valve-related complications including prosthesis-patient mismatch. Other evaluations are medical history, physical examination, echocardiography, MRI, rhythm monitoring and laboratory evaluation (including NT-proBNP).Identification of the relation between prosthetic valve characteristics in ACHD patients on one hand and functional outcome, QoL, the prevalence and predictors of prosthesis-related complications on the other hand may influence the choice of valve prosthesis, the indication for more extensive surgery and the indication for re-operation.

KW - Congenital heart disease

KW - Prosthesis-patient mismatch

KW - Prosthetic heart valve

KW - Valvular heart disease

KW - Functional outcome

KW - Quality of life

KW - QUALITY-OF-LIFE

KW - MECHANICAL PROSTHESIS

KW - REPLACEMENT

KW - MISMATCH

KW - PREGNANCY

KW - CHILDREN

KW - IMPACT

KW - MORTALITY

KW - POSITION

KW - WOMEN

U2 - 10.1007/s12471-012-0308-4

DO - 10.1007/s12471-012-0308-4

M3 - Article

SN - 1568-5888

VL - 20

SP - 419

EP - 424

JO - Netherlands Heart Journal

JF - Netherlands Heart Journal

IS - 10

ER -

Prosthetic valves in adult patients with congenital heart disease: Rationale and design of the Dutch PROSTAVA study

Abstract

Keywords

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