Protective role of endothelial nitric oxide synthase

Ester W J A Albrecht; Coen A Stegeman; Peter Heeringa; Robert Henning; Harry van Goor

doi:10.1002/path.1250

Protective role of endothelial nitric oxide synthase

Ester W J A Albrecht, Coen A Stegeman, Peter Heeringa, Robert Henning, Harry van Goor

Research output: Contribution to journal › Review article › peer-review

336 Citations (Scopus)

Abstract

Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to anti-proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the nitric oxide synthases, endothelial NOS (eNOS), neural NOS (nNOS), and inducible NOS (iNOS). Constitutively expressed eNOS produces low concentrations of NO, which is necessary for a good endothelial function and integrity. Endothelial derived NO is often seen as a protective agent in a variety of diseases. This review will focus on the potential protective role of eNOS. We will discuss recent data derived from studies in eNOS knockout mice and other experimental models. Furthermore, the role of eNOS in human diseases is described and possible therapeutic intervention strategies will be discussed.

Original language	English
Pages (from-to)	8-17
Number of pages	10
Journal	The Journal of Pathology
Volume	199
Issue number	1
DOIs	https://doi.org/10.1002/path.1250
Publication status	Published - Jan-2003

Keywords

nitric oxide
endothelial nitric oxide synthase
endothelium
endothelial dysfunction
vascular tone
knockout mice
pharmacological inhibition
CORONARY-ARTERY DISEASE
ISCHEMIA-REPERFUSION INJURY
L-ARGININE SUPPLEMENTATION
VASCULAR SMOOTH-MUSCLE
PEROXYNITRITE-MODIFIED PROTEINS
SALT-SENSITIVE HYPERTENSION
RENAL OXYGEN-CONSUMPTION
INDUCED UP-REGULATION
GENE-EXPRESSION
KNOCKOUT MICE

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title = "Protective role of endothelial nitric oxide synthase",

abstract = "Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to anti-proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the nitric oxide synthases, endothelial NOS (eNOS), neural NOS (nNOS), and inducible NOS (iNOS). Constitutively expressed eNOS produces low concentrations of NO, which is necessary for a good endothelial function and integrity. Endothelial derived NO is often seen as a protective agent in a variety of diseases. This review will focus on the potential protective role of eNOS. We will discuss recent data derived from studies in eNOS knockout mice and other experimental models. Furthermore, the role of eNOS in human diseases is described and possible therapeutic intervention strategies will be discussed.",

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T1 - Protective role of endothelial nitric oxide synthase

AU - Albrecht, Ester W J A

AU - Stegeman, Coen A

AU - Heeringa, Peter

AU - Henning, Robert

AU - van Goor, Harry

PY - 2003/1

Y1 - 2003/1

N2 - Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to anti-proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the nitric oxide synthases, endothelial NOS (eNOS), neural NOS (nNOS), and inducible NOS (iNOS). Constitutively expressed eNOS produces low concentrations of NO, which is necessary for a good endothelial function and integrity. Endothelial derived NO is often seen as a protective agent in a variety of diseases. This review will focus on the potential protective role of eNOS. We will discuss recent data derived from studies in eNOS knockout mice and other experimental models. Furthermore, the role of eNOS in human diseases is described and possible therapeutic intervention strategies will be discussed.

AB - Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to anti-proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the nitric oxide synthases, endothelial NOS (eNOS), neural NOS (nNOS), and inducible NOS (iNOS). Constitutively expressed eNOS produces low concentrations of NO, which is necessary for a good endothelial function and integrity. Endothelial derived NO is often seen as a protective agent in a variety of diseases. This review will focus on the potential protective role of eNOS. We will discuss recent data derived from studies in eNOS knockout mice and other experimental models. Furthermore, the role of eNOS in human diseases is described and possible therapeutic intervention strategies will be discussed.

KW - nitric oxide

KW - endothelial nitric oxide synthase

KW - endothelium

KW - endothelial dysfunction

KW - vascular tone

KW - knockout mice

KW - pharmacological inhibition

KW - CORONARY-ARTERY DISEASE

KW - ISCHEMIA-REPERFUSION INJURY

KW - L-ARGININE SUPPLEMENTATION

KW - VASCULAR SMOOTH-MUSCLE

KW - PEROXYNITRITE-MODIFIED PROTEINS

KW - SALT-SENSITIVE HYPERTENSION

KW - RENAL OXYGEN-CONSUMPTION

KW - INDUCED UP-REGULATION

KW - GENE-EXPRESSION

KW - KNOCKOUT MICE

U2 - 10.1002/path.1250

DO - 10.1002/path.1250

M3 - Review article

C2 - 12474221

SN - 0022-3417

VL - 199

SP - 8

EP - 17

JO - The Journal of Pathology

JF - The Journal of Pathology

IS - 1

ER -

Protective role of endothelial nitric oxide synthase

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Keywords

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