Protein crystallography for computation-supported enzyme redesign

Nikolas Capra

doi:10.33612/diss.915200773

Protein crystallography for computation-supported enzyme redesign

Nikolas Capra

Biotechnology

Research output: Thesis › Thesis fully internal (DIV)

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Abstract

The main focus of the thesis is the application of structural analysis as validation method of computational protein design strategies. The thesis investigates the structure-function relationships of enzymes, and x-ray crystallography is used to critically validate theoretically designed mutations aimed to improve enzyme’s stability or catalytic properties.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Groningen
Supervisors/Advisors	Janssen, Dick, Supervisor Fraaije, Marco, Supervisor Thunnissen, Andy, Co-supervisor
Award date	2-Apr-2024
Place of Publication	[Groningen]
Publisher	University of Groningen
DOIs	https://doi.org/10.33612/diss.915200773
Publication status	Published - 2024

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10.33612/diss.915200773

Title and contentsFinal publisher's version, 6.08 MB
Chapter 1Final publisher's version, 4.99 MB
Chapter 2Final publisher's version, 5.39 MB
Chapter 3Final publisher's version, 4.81 MB
Chapter 4Final publisher's version, 5.09 MB
Chapter 5Final publisher's version, 4.59 MB
Chapter 6Final publisher's version, 5.63 MB
Chapter 7Final publisher's version, 1.68 MB
AppendicesFinal publisher's version, 1.91 MB
Complete thesisFinal publisher's version, 17.2 MB
PropositionsFinal publisher's version, 118 KB

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title = "Protein crystallography for computation-supported enzyme redesign",

abstract = "The main focus of the thesis is the application of structural analysis as validation method of computational protein design strategies. The thesis investigates the structure-function relationships of enzymes, and x-ray crystallography is used to critically validate theoretically designed mutations aimed to improve enzyme{\textquoteright}s stability or catalytic properties.",

author = "Nikolas Capra",

year = "2024",

doi = "10.33612/diss.915200773",

language = "English",

publisher = "University of Groningen",

school = "University of Groningen",

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AB - The main focus of the thesis is the application of structural analysis as validation method of computational protein design strategies. The thesis investigates the structure-function relationships of enzymes, and x-ray crystallography is used to critically validate theoretically designed mutations aimed to improve enzyme’s stability or catalytic properties.

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DO - 10.33612/diss.915200773

M3 - Thesis fully internal (DIV)

PB - University of Groningen

CY - [Groningen]

ER -

Protein crystallography for computation-supported enzyme redesign

Abstract

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