Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics

Frank J Dekker, Marcus A Koch, Herbert Waldmann, Frans Dekker

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)

Abstract

Finding small molecules that modulate protein function is of primary importance in drug development and in the emerging field of chemical genomics. To facilitate the identification of such molecules, we developed a novel strategy making use of structural conservatism found in protein domain architecture and natural product inspired compound library design. Domains and proteins identified as being structurally similar in their ligand-sensing cores are grouped in a protein structure similarity cluster (PSSC). Natural products can be considered as evolutionary pre-validated ligands for multiple proteins and therefore natural products that are known to interact with one of the PSSC member proteins are selected as guiding structures for compound library synthesis. Application of this novel strategy for compound library design provided enhanced hit rates in small compound libraries for structurally similar proteins.

Original languageEnglish
Pages (from-to)232-9
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume9
Issue number3
DOIs
Publication statusPublished - Jun-2005

Keywords

  • Biological Factors
  • Combinatorial Chemistry Techniques
  • Databases, Protein
  • Drug Design
  • Genomics
  • Ligands
  • Models, Molecular
  • Protein Conformation
  • Proteins

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