Proton therapy for pediatric malignancies: Fact, figures and costs. A joint consensus statement from the pediatric subcommittee of PTCOG, PROS and EPTN

Damien C. Weber*, Jean Louis Habrand, Bradford S. Hoppe, Christine Hill Kayser, Nadia N. Laack, Johanes A. Langendijk, Shannon M. MacDonald, Susan L. McGovern, Luke Pater, John P. Perentesis, Juliette Thariat, Beate Timmerman, Torunn I. Yock, Anita Mahajan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Radiotherapy plays an important role in the management of childhood cancer, with the primary aim of achieving the highest likelihood of cure with the lowest risk of radiation-induced morbidity. Proton therapy (PT) provides an undisputable advantage by reducing the radiation 'bath' dose delivered to non-target structures/volume while optimally covering the tumor with tumoricidal dose. This treatment modality comes, however, with an additional costs compared to conventional radiotherapy that could put substantial financial pressure to the health care systems with societal implications. In this review we assess the data available to the oncology community of PT delivered to children with cancer, discuss on the urgency to develop high-quality data. Additionally, we look at the advantage of combining systemic agents with protons and look at the cost-effectiveness data published so far. (C) 2018 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)44-55
Number of pages12
JournalRadiotherapy and Oncology
Volume128
Issue number1
DOIs
Publication statusPublished - Jul-2018

Keywords

  • Proton therapy
  • CNS tumors
  • Sarcoma
  • Children
  • Pediatric cancer
  • Lymphoma
  • CENTRAL-NERVOUS-SYSTEM
  • ATYPICAL TERATOID/RHABDOID TUMOR
  • MODULATED RADIATION-THERAPY
  • CHILDHOOD-CANCER SURVIVOR
  • CHILDRENS ONCOLOGY GROUP
  • GERM-CELL TUMORS
  • ADVANCED PHOTON RADIOTHERAPY
  • INITIAL CLINICAL-OUTCOMES
  • TERATOID RHABDOID TUMORS
  • PAUL-SCHERRER-INSTITUTE

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