Psychosexual development and satisfaction in long-term survivors of childhood cancer: Neurotoxic treatment intensity as a risk indicator

Vicky Lehmann*, Marrit Tuinman, Madelaine C. Keim, Adrien M. Winning, Randal S. Olshefski, Rajinder P. S. Bajwa, Mariet Hagedoorn, Cynthia A. Gerhardt

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

BACKGROUNDRisk factors for impairment in psychosexual development and satisfaction among adult survivors of childhood cancer are poorly understood. The authors compared psychosexual outcomes between survivors and healthy controls, and tested whether at-risk survivors can be identified by 1) treatment neurotoxicity or 2) diagnosis.

METHODSA total of 144 young adult survivors of childhood cancer and 144 matched controls completed questionnaires regarding psychosexual development, sexual satisfaction, and satisfaction with relationship status. Survivors were aged 20 to 40 years and were 5 to 34 years after diagnosis. Using medical chart data, survivors were divided into non-neurotoxic (48 survivors), low-dose (36 survivors), and high-dose (58 survivors) neurotoxic treatment groups.

RESULTSApart from having fewer lifetime sex partners, survivors did not appear to differ from controls. However, survivors of brain tumors and any survivor who received high-dose neurotoxic treatment reported the lowest rates of achieving milestones of psychosexual development, whereas sexual and relationship status satisfaction were found to be related to relationship status. Neurotoxic treatment intensity further distinguished between survivors of brain tumors with and without psychosexual impairment.

CONCLUSIONSThe intensity of neurotoxic treatment may be a valuable indicator of risk for psychosexual impairment relative to diagnosis alone. Health care providers should assess romantic/sexual problems among survivors at risk and make referrals if needed. Cancer 2017;123:1869-1876. (c) 2017 American Cancer Society.

The results of the current study indicate that adult survivors of childhood cancer do not differ from healthy controls with regard to their psychosexual development, sexual satisfaction, and relationship status satisfaction. However, more intense neurotoxic treatment appears to be associated with a higher risk of psychosexual impairment, and may be a more meaningful risk indicator than diagnostic category alone.

Original languageEnglish
Pages (from-to)1869-1876
Number of pages8
JournalCancer
Volume123
Issue number10
DOIs
Publication statusPublished - 15-May-2017

Keywords

  • childhood cancer
  • long-term survivors
  • neurotoxicity
  • psychosexual development
  • sexual satisfaction
  • ACUTE LYMPHOBLASTIC-LEUKEMIA
  • YOUNG-ADULT SURVIVORS
  • SOCIAL OUTCOMES
  • SEXUAL FUNCTION
  • NEUROCOGNITIVE OUTCOMES
  • ADOLESCENT CANCER
  • CRANIAL RADIATION
  • PEDIATRIC CANCER
  • FEMALE SURVIVORS
  • BRAIN-TUMORS

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