Pulmonary biomarkers in chronic obstructive pulmonary disease

Peter J. Barnes*, Badrul Chowdhury, Sergei A. Kharitonov, Helgo Magnussen, Clive P. Page, Dirkje Postma, Marina Saetta

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

225 Citations (Scopus)

Abstract

There has been increasing interest in using pulmonary biomarkers to understand and monitor the inflammation in the respiratory tract of patients with chronic obstructive pulmonary disease (COPD). In this Pulmonary Perspective we discuss the merits of the various approaches by reviewing the current literature on pulmonary biomarkers in COPD and underscore the need for more systematic studies in the future. Bronchial biopsies and bronchoalveolar lavage provide valuable information about inflammatory cells and mediators, but are invasive, so that repeated measurements have to be very limited in assessing any interventions. Induced sputum has provided considerable information about the inflammatory process, including mediators and proteinases in COPD, but selectively samples proximal airways and may not closely reflect distal inflammatory processes. Exhaled gases and breath condensate are noninvasive procedures, so repeated measurements are possible, but for some assays the variability is relatively high. There is relatively little information about how any of these biomarkers relate to other clinical outcomes, such as progression of the disease, severity of disease, clinical subtypes, or response to therapy. More information is also needed about the variability in these measurements. In the future, pulmonary biomarkers may be useful in predicting disease progression, indicating disease instability, and in predicting response to current therapies and novel therapies, many of which are now in development.

Original languageEnglish
Pages (from-to)6-14
Number of pages9
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume174
Issue number1
DOIs
Publication statusPublished - 1-Jul-2006

Keywords

  • bronchial biopsy
  • bronchoalveolar lavage
  • exhaled breath
  • condensate
  • exhaled nitric oxide
  • induced sputum
  • EXHALED BREATH CONDENSATE
  • BRONCHOALVEOLAR LAVAGE FLUID
  • RANDOMIZED CONTROLLED-TRIAL
  • NITRIC-OXIDE MEASUREMENTS
  • AIR-FLOW OBSTRUCTION
  • SPUTUM INFLAMMATORY MARKERS
  • SHORT-TERM RESPONSE
  • CHRONIC-BRONCHITIS
  • OXIDATIVE STRESS
  • SMOKING-CESSATION

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