Pulmonary involvement during cytomegalovirus infection in immunosuppressed patients

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Although cytomegalovirus (CMV) pulmonary involvement after solid organ transplantation is infrequently seen nowadays, CMV pneumonitis is still a potential lethal complication. Introduction of the pp65 antigenemia assay enabled early and rapid diagnosis of CMV viremia in transplant patients prior to symptoms. Also, in asymptomatic patients with CMV viremia, a decreased pulmonary diffusion capacity could be demonstrated. In this review, we discuss clinical and subclinical pulmonary involvement of CMV infection in the immunocompromised host with an emphasis on transplant recipients. The clinical course, diagnosis, therapy, prophylaxis, and pathophysiology of CMV pneumonitis are discussed.

Original languageEnglish
Pages (from-to)112-120
Number of pages9
JournalTransplant Infectious Disease
Volume5
Issue number3
DOIs
Publication statusPublished - Sept-2003

Keywords

  • Animals
  • Antiviral Agents/therapeutic use
  • Cytomegalovirus/isolation & purification
  • Cytomegalovirus Infections/diagnosis
  • Humans
  • Immunocompromised Host
  • Mice
  • Organ Transplantation/adverse effects
  • Pneumonia, Viral/diagnosis

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