Putting a Hold on the Downward Spiral of Paranoia in the Social World: A Randomized Controlled Trial of Mindfulness-Based Cognitive Therapy in Individuals with a History of Depression

Dina Collip*, Nicole Geschwind, Frenk Peeters, Inez Myin-Germeys, Jim van Os, Marieke Wichers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)
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Abstract

Context: Paranoia embodies altered representation of the social environment, fuelling altered feelings of social acceptance leading to further mistrust. Mindfulness-based cognitive therapy (MBCT) may relieve paranoia and reduce its impact on social acceptance.

Objective: To determine whether MBCT alters momentary feeling of paranoia and social acceptance in daily life.

Design: Randomized controlled trial of daily-life repeated measures (up to 120 per participant) before and after allocation to MBCT or waiting list control.

Participants: Volunteer sample of 130 eligible men and women with residual affective dysregulation after at least one episode of major depressive disorder.

Interventions: Eight weeks of MBCT in groups of 10-15 participants in addition to participants' usual treatment.

Outcome Measures: Daily-life ratings of paranoia and social acceptance. This manuscript concerns additional analyses of the original trial; hypotheses were developed after data collection (focus initially on depressive symptoms) but before data analysis.

Results: Sixty-six participants were assigned to the waiting list control group and 64 to the MBCT intervention group, of whom 66 and 61 respectively were included in the per-protocol analyses. Intention-to-treat analyses revealed a significant group by time interaction in the model of momentary paranoia (b = -.18, p

Conclusions: MBCT confers a substantial benefit on subclinical paranoia and may interrupt the social processes that maintain and foster paranoia in individuals with residual affective dysregulation.

Original languageEnglish
Article numbere66747
Number of pages7
JournalPLoS ONE
Volume8
Issue number6
DOIs
Publication statusPublished - 27-Jun-2013
Externally publishedYes

Keywords

  • COMMITMENT THERAPY
  • DAILY-LIFE
  • PSYCHOTIC SYMPTOMS
  • ACCEPTANCE
  • SCHIZOPHRENIA
  • DISORDERS
  • ENVIRONMENT
  • EXPERIENCE
  • DELUSIONS
  • PREVENT

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