Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer

Inge M. Oskam, Irma M. Verdonck-de Leeuw*, Neil K. Aaronson, Dirk J. Kuik, Remco de Bree, Patricia Doornaert, Johannes A. Langendijk, C. Rene Leemans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background and purpose: The realtion between health-related quality of life (HRQOL) and survival was investigated at baseline and 6 months in 80 patients with advanced oral or oropharyngeal cancer after microvascular reconstructive surgery and (almost all) adjuvant radiotherapy.

Materials and methods: Multivariate Cox regression analyses of overall and disease-specific survival were performed including sciodemographic (age, gender, marital status, comorbidity), and clinical (tumor stage and site, radical surgical, metastasis, radiotherapy) pharameters, and HRQOL (EORTC QLQ-C30 global quality of life scale).

Results: before treatment, younger age and having a partner were predictors of disease-specific survival; younger age predicted overall survival. At 6 months post-treatment, disease-specific and overall survival was predicted by (deterioration of) global quality of life solely. Global health-related quality of life after treatment was mainly influenced by emotional functioning.

Conclusion: Deterioration of global quality of life after treatment is an independent predictor of survival in patients with advanced oral or oropharyngeal cancer. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 258-262

Original languageEnglish
Pages (from-to)258-262
Number of pages5
JournalRadiotherapy and Oncology
Volume97
Issue number2
DOIs
Publication statusPublished - Nov-2010

Keywords

  • Head and neck cancer
  • Oropharyngeal cancer
  • Health-related quality of life
  • Survival
  • SQUAMOUS-CELL CARCINOMA
  • LONG-TERM SURVIVAL
  • NECK-CANCER
  • LONGITUDINAL ASSESSMENT
  • SURGICAL-TREATMENT
  • SOCIODEMOGRAPHIC FACTORS
  • PSYCHOSOCIAL FACTORS
  • MICROVASCULAR FLAP
  • HEAD
  • DISTRESS

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