Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer

Inge M. Oskam; Irma M. Verdonck-de Leeuw; Neil K. Aaronson; Dirk J. Kuik; Remco de Bree; Patricia Doornaert; Johannes A. Langendijk; C. Rene Leemans

doi:10.1016/j.radonc.2010.02.005

Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer

Inge M. Oskam
, Irma M. Verdonck-de Leeuw^*
, Neil K. Aaronson
, Dirk J. Kuik
, Remco de Bree
, Patricia Doornaert
, Johannes A. Langendijk
, C. Rene Leemans

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

56 Citations (Scopus)

Abstract

Background and purpose: The realtion between health-related quality of life (HRQOL) and survival was investigated at baseline and 6 months in 80 patients with advanced oral or oropharyngeal cancer after microvascular reconstructive surgery and (almost all) adjuvant radiotherapy.

Materials and methods: Multivariate Cox regression analyses of overall and disease-specific survival were performed including sciodemographic (age, gender, marital status, comorbidity), and clinical (tumor stage and site, radical surgical, metastasis, radiotherapy) pharameters, and HRQOL (EORTC QLQ-C30 global quality of life scale).

Results: before treatment, younger age and having a partner were predictors of disease-specific survival; younger age predicted overall survival. At 6 months post-treatment, disease-specific and overall survival was predicted by (deterioration of) global quality of life solely. Global health-related quality of life after treatment was mainly influenced by emotional functioning.

Conclusion: Deterioration of global quality of life after treatment is an independent predictor of survival in patients with advanced oral or oropharyngeal cancer. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 258-262

Original language	English
Pages (from-to)	258-262
Number of pages	5
Journal	Radiotherapy and Oncology
Volume	97
Issue number	2
DOIs	https://doi.org/10.1016/j.radonc.2010.02.005
Publication status	Published - Nov-2010

Keywords

Head and neck cancer
Oropharyngeal cancer
Health-related quality of life
Survival
SQUAMOUS-CELL CARCINOMA
LONG-TERM SURVIVAL
NECK-CANCER
LONGITUDINAL ASSESSMENT
SURGICAL-TREATMENT
SOCIODEMOGRAPHIC FACTORS
PSYCHOSOCIAL FACTORS
MICROVASCULAR FLAP
HEAD
DISTRESS

Access to Document

10.1016/j.radonc.2010.02.005

Handle.net

Persistent link

Cite this

Oskam, I. M., Verdonck-de Leeuw, I. M., Aaronson, N. K., Kuik, D. J., de Bree, R., Doornaert, P., Langendijk, J. A., & Leemans, C. R. (2010). Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer. Radiotherapy and Oncology, 97(2), 258-262. https://doi.org/10.1016/j.radonc.2010.02.005

@article{f5e73b449ac7411eb5515814738fa814,

title = "Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer",

abstract = "Background and purpose: The realtion between health-related quality of life (HRQOL) and survival was investigated at baseline and 6 months in 80 patients with advanced oral or oropharyngeal cancer after microvascular reconstructive surgery and (almost all) adjuvant radiotherapy.Materials and methods: Multivariate Cox regression analyses of overall and disease-specific survival were performed including sciodemographic (age, gender, marital status, comorbidity), and clinical (tumor stage and site, radical surgical, metastasis, radiotherapy) pharameters, and HRQOL (EORTC QLQ-C30 global quality of life scale).Results: before treatment, younger age and having a partner were predictors of disease-specific survival; younger age predicted overall survival. At 6 months post-treatment, disease-specific and overall survival was predicted by (deterioration of) global quality of life solely. Global health-related quality of life after treatment was mainly influenced by emotional functioning.Conclusion: Deterioration of global quality of life after treatment is an independent predictor of survival in patients with advanced oral or oropharyngeal cancer. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 258-262",

keywords = "Head and neck cancer, Oropharyngeal cancer, Health-related quality of life, Survival, SQUAMOUS-CELL CARCINOMA, LONG-TERM SURVIVAL, NECK-CANCER, LONGITUDINAL ASSESSMENT, SURGICAL-TREATMENT, SOCIODEMOGRAPHIC FACTORS, PSYCHOSOCIAL FACTORS, MICROVASCULAR FLAP, HEAD, DISTRESS",

author = "Oskam, \{Inge M.\} and \{Verdonck-de Leeuw\}, \{Irma M.\} and Aaronson, \{Neil K.\} and Kuik, \{Dirk J.\} and \{de Bree\}, Remco and Patricia Doornaert and Langendijk, \{Johannes A.\} and Leemans, \{C. Rene\}",

year = "2010",

month = nov,

doi = "10.1016/j.radonc.2010.02.005",

language = "English",

volume = "97",

pages = "258--262",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "ELSEVIER IRELAND LTD",

number = "2",

}

Oskam, IM, Verdonck-de Leeuw, IM, Aaronson, NK, Kuik, DJ, de Bree, R, Doornaert, P, Langendijk, JA & Leemans, CR 2010, 'Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer', Radiotherapy and Oncology, vol. 97, no. 2, pp. 258-262. https://doi.org/10.1016/j.radonc.2010.02.005

Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer. / Oskam, Inge M.; Verdonck-de Leeuw, Irma M.; Aaronson, Neil K. et al.
In: Radiotherapy and Oncology, Vol. 97, No. 2, 11.2010, p. 258-262.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Quality of life as predictor of survival

T2 - A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer

AU - Oskam, Inge M.

AU - Verdonck-de Leeuw, Irma M.

AU - Aaronson, Neil K.

AU - Kuik, Dirk J.

AU - de Bree, Remco

AU - Doornaert, Patricia

AU - Langendijk, Johannes A.

AU - Leemans, C. Rene

PY - 2010/11

Y1 - 2010/11

N2 - Background and purpose: The realtion between health-related quality of life (HRQOL) and survival was investigated at baseline and 6 months in 80 patients with advanced oral or oropharyngeal cancer after microvascular reconstructive surgery and (almost all) adjuvant radiotherapy.Materials and methods: Multivariate Cox regression analyses of overall and disease-specific survival were performed including sciodemographic (age, gender, marital status, comorbidity), and clinical (tumor stage and site, radical surgical, metastasis, radiotherapy) pharameters, and HRQOL (EORTC QLQ-C30 global quality of life scale).Results: before treatment, younger age and having a partner were predictors of disease-specific survival; younger age predicted overall survival. At 6 months post-treatment, disease-specific and overall survival was predicted by (deterioration of) global quality of life solely. Global health-related quality of life after treatment was mainly influenced by emotional functioning.Conclusion: Deterioration of global quality of life after treatment is an independent predictor of survival in patients with advanced oral or oropharyngeal cancer. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 258-262

AB - Background and purpose: The realtion between health-related quality of life (HRQOL) and survival was investigated at baseline and 6 months in 80 patients with advanced oral or oropharyngeal cancer after microvascular reconstructive surgery and (almost all) adjuvant radiotherapy.Materials and methods: Multivariate Cox regression analyses of overall and disease-specific survival were performed including sciodemographic (age, gender, marital status, comorbidity), and clinical (tumor stage and site, radical surgical, metastasis, radiotherapy) pharameters, and HRQOL (EORTC QLQ-C30 global quality of life scale).Results: before treatment, younger age and having a partner were predictors of disease-specific survival; younger age predicted overall survival. At 6 months post-treatment, disease-specific and overall survival was predicted by (deterioration of) global quality of life solely. Global health-related quality of life after treatment was mainly influenced by emotional functioning.Conclusion: Deterioration of global quality of life after treatment is an independent predictor of survival in patients with advanced oral or oropharyngeal cancer. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 258-262

KW - Head and neck cancer

KW - Oropharyngeal cancer

KW - Health-related quality of life

KW - Survival

KW - SQUAMOUS-CELL CARCINOMA

KW - LONG-TERM SURVIVAL

KW - NECK-CANCER

KW - LONGITUDINAL ASSESSMENT

KW - SURGICAL-TREATMENT

KW - SOCIODEMOGRAPHIC FACTORS

KW - PSYCHOSOCIAL FACTORS

KW - MICROVASCULAR FLAP

KW - HEAD

KW - DISTRESS

U2 - 10.1016/j.radonc.2010.02.005

DO - 10.1016/j.radonc.2010.02.005

M3 - Article

SN - 0167-8140

VL - 97

SP - 258

EP - 262

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 2

ER -

Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this