Quantification of coronary artery calcium in nongated CT to predict cardiovascular events in male lung cancer screening participants: Results of the NELSON study

Richard A. P. Takx*, Ivana Isgum, Martin J. Willemink, Yolanda van der Graaf, Harry J. de Koning, Rozemarijn Vliegenthart, Matthijs Oudkerk, Tim Leiner, Pim A. de Jong

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Objective: To evaluate the incremental prognostic value of the number and maximum volume of coronary artery calcifications over modified Agatston score strata, age, pack-years, and smoking status for predicting cardiovascular events.

Methods: A total of 3559 male current and former smokers received a CT examination for lung cancer screening. Smoking characteristics, patient demographics, and physician-diagnosed cardiovascular events were collected. Images were acquired without electro-cardiography gating on 16-slice CT scanners. The association between the presence of both fatal and nonfatal cardiovascular events and the predictors was quantified using Cox proportional hazard analysis.

Results: Median follow-up period was 2.9 years. Incident cardiovascular events occurred in 186 participants. Adjusted hazard ratios for modified Agatston score strata of 1 to 10, 11 to 100, 101 to 400, and >400 were 3.39 (95% confidence interval [CI], 1.20-9.59), 6.52 (95% CI, 2.73-15.60), 6.58 (95% CI, 2.75-15.78), and 12.58, (95% CI, 5.42-29.16), respectively. Moreover, comparing the models with and without Modified Agatston score strata to the model with age, pack-years, and smoking status yielded a significantly better net reclassification improvement (NRI; 27.3%; P <.0001). Adding the number of calcifications to the model with age, pack-years, smoking status, and modified Agatston score strata resulted in a slightly better NRI (1.68%; P = .0490) with a hazard ratio of 1.13 (95% CI, 1.05-1.21) per 10 calcificatiOns. The incremental prognostic information contained in the volume of the largest calcification was not statistically significant (NRI, 0.14%; P = .3458).

Conclusion: Cardiovascular event rate increased with higher numbers of calcified lesions. The number but not maximum volume of calcifications has independent, although minimal, prognostic value over age, pack-years, smoking status, and modified Agatston score strata in our population. (C) 2015 Society of Cardiovascular Computed Tomography. All rights reserved.

Original languageEnglish
Pages (from-to)50-57
Number of pages8
JournalJournal of Cardiovascular Computed Tomography
Volume9
Issue number1
DOIs
Publication statusPublished - 2015

Keywords

  • Lung cancer screening
  • Computed tomography
  • Cardiovascular event
  • AMERICAN-HEART-ASSOCIATION
  • PROGNOSTIC VALUE
  • COMPUTED-TOMOGRAPHY
  • RISK
  • CALCIFICATION
  • DISEASE
  • SCORE
  • ATHEROSCLEROSIS
  • TRIAL
  • EPIDEMIOLOGY

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