Quantification of ion-induced molecular fragmentation of isolated 2-deoxy-D-ribose molecules

F. Alvarado Chacon, S. Bari, R.A. Hoekstra, T.A. Schlathölter

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Abstract

Recent experiments on low energy ion-induced damage to DNA building blocks indicate that ion induced DNA damage is dominated by deoxyribose disintegration (Phys. Rev. Lett., 2005, 95, 153201). We have studied interactions of keV H+ and Heq+ with isolated deoxyribose molecules by means of high resolution time-of-flight spectrometry. Extensive statistical fragmentation of the molecules is observed. The fragment distribution is found to follow a power law dependence. The exponent can be used to characterize and quantify the molecular damage.

Original languageEnglish
Pages (from-to)1922-1928
Number of pages7
JournalPhysical Chemistry Chemical Physics
Volume8
Issue number16
DOIs
Publication statusPublished - 2006

Keywords

  • ENERGY HEAVY-IONS
  • STRAND BREAKS
  • COLLISIONS
  • IONIZATION
  • HYDROGEN
  • THYMINE
  • DNA
  • DEOXYRIBOSE
  • EXCITATION
  • ASTEROIDS

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