Quantification of liver iron concentration with magnetic resonance imaging by combining T1-, T2-weighted spin echo sequences and a gradient echo sequence

HG Kreeftenberg*, EL Mooyaart, WJ Sluiter, Reint Huizenga

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    32 Citations (Scopus)

    Abstract

    Background: The aim of the study was to quantify hepatic iron by MRI for practical use. Methods: In twenty-three patients with various degrees of iron overload, measurements were carried out with a 1.5 Tesla MR unit. A combination of pulse sequences (T1, T2 and gradient echo) enabled us to quantify smaller amounts of liver iron as accurately as larger amounts of liver iron. The gradient echo sequence provided us with a good correlation when detecting smaller amounts of iron in the liver where the T1 sequence provided a good correlation when larger amounts of iron were present. Results: The combination of the three sequences showed a nice correlation (r = - 0.93, P

    Original languageEnglish
    Pages (from-to)133-137
    Number of pages5
    JournalNetherlands Journal of Medicine
    Volume56
    Issue number4
    DOIs
    Publication statusPublished - Apr-2000

    Keywords

    • magnetic resonance imaging
    • haemochromatosis
    • liver iron concentration
    • THALASSEMIA MAJOR
    • HEMOCHROMATOSIS
    • OVERLOAD
    • DIAGNOSIS
    • DISEASE

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