Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11

Judith Nijmeijer; Alejandro Arias-Vasquez; Nanda N. J. Rommelse; Marieke E. Altink; Cathelijne J. M. Buschgens; Ellen A. Fliers; Barbara Franke; Rudolf Minderaa; Joseph A. Sergeant; Jan K. Buitelaar; Pieter J. Hoekstra; Catharina A. Hartman

doi:10.1007/s10803-014-2039-4

Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11

Judith Nijmeijer, Alejandro Arias-Vasquez, Nanda N. J. Rommelse, Marieke E. Altink, Cathelijne J. M. Buschgens, Ellen A. Fliers, Barbara Franke, Rudolf Minderaa, Joseph A. Sergeant, Jan K. Buitelaar, Pieter J. Hoekstra, Catharina A. Hartman

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Abstract

We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children's Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing.

Original language	English
Pages (from-to)	1671-1680
Number of pages	10
Journal	Journal of Autism and Developmental Disorders
Volume	44
Issue number	7
DOIs	https://doi.org/10.1007/s10803-014-2039-4
Publication status	Published - Jul-2014

Keywords

ASD
ADHD
Comorbidity
Genetics
DEFICIT HYPERACTIVITY DISORDER
WILLIAMS-BEUREN-SYNDROME
GENERAL-POPULATION
GENETIC INFLUENCES
SOCIAL-BEHAVIOR
TWIN SAMPLE
SIB PAIRS
GENOME
TRAITS
SCAN

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Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit-HyperactivityFinal publisher's version, 390 KBLicence: Taverne

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Nijmeijer, J., Arias-Vasquez, A., Rommelse, N. N. J., Altink, M. E., Buschgens, C. J. M., Fliers, E. A., Franke, B., Minderaa, R., Sergeant, J. A., Buitelaar, J. K., Hoekstra, P. J., & Hartman, C. A. (2014). Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11. Journal of Autism and Developmental Disorders, 44(7), 1671-1680. https://doi.org/10.1007/s10803-014-2039-4

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title = "Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11",

abstract = "We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children's Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing.",

keywords = "ASD, ADHD, Comorbidity, Genetics, DEFICIT HYPERACTIVITY DISORDER, WILLIAMS-BEUREN-SYNDROME, GENERAL-POPULATION, GENETIC INFLUENCES, SOCIAL-BEHAVIOR, TWIN SAMPLE, SIB PAIRS, GENOME, TRAITS, SCAN",

author = "Judith Nijmeijer and Alejandro Arias-Vasquez and Rommelse, {Nanda N. J.} and Altink, {Marieke E.} and Buschgens, {Cathelijne J. M.} and Fliers, {Ellen A.} and Barbara Franke and Rudolf Minderaa and Sergeant, {Joseph A.} and Buitelaar, {Jan K.} and Hoekstra, {Pieter J.} and Hartman, {Catharina A.}",

year = "2014",

month = jul,

doi = "10.1007/s10803-014-2039-4",

language = "English",

volume = "44",

pages = "1671--1680",

journal = "Journal of Autism and Developmental Disorders",

issn = "0162-3257",

publisher = "SPRINGER/PLENUM PUBLISHERS",

number = "7",

}

Nijmeijer, J, Arias-Vasquez, A, Rommelse, NNJ, Altink, ME, Buschgens, CJM, Fliers, EA, Franke, B, Minderaa, R, Sergeant, JA, Buitelaar, JK, Hoekstra, PJ & Hartman, CA 2014, 'Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11', Journal of Autism and Developmental Disorders, vol. 44, no. 7, pp. 1671-1680. https://doi.org/10.1007/s10803-014-2039-4

Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11. / Nijmeijer, Judith; Arias-Vasquez, Alejandro; Rommelse, Nanda N. J. et al.
In: Journal of Autism and Developmental Disorders, Vol. 44, No. 7, 07.2014, p. 1671-1680.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder

T2 - Significant Locus on Chromosome 7q11

AU - Nijmeijer, Judith

AU - Arias-Vasquez, Alejandro

AU - Rommelse, Nanda N. J.

AU - Altink, Marieke E.

AU - Buschgens, Cathelijne J. M.

AU - Fliers, Ellen A.

AU - Franke, Barbara

AU - Minderaa, Rudolf

AU - Sergeant, Joseph A.

AU - Buitelaar, Jan K.

AU - Hoekstra, Pieter J.

AU - Hartman, Catharina A.

PY - 2014/7

Y1 - 2014/7

N2 - We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children's Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing.

AB - We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children's Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing.

KW - ASD

KW - ADHD

KW - Comorbidity

KW - Genetics

KW - DEFICIT HYPERACTIVITY DISORDER

KW - WILLIAMS-BEUREN-SYNDROME

KW - GENERAL-POPULATION

KW - GENETIC INFLUENCES

KW - SOCIAL-BEHAVIOR

KW - TWIN SAMPLE

KW - SIB PAIRS

KW - GENOME

KW - TRAITS

KW - SCAN

U2 - 10.1007/s10803-014-2039-4

DO - 10.1007/s10803-014-2039-4

M3 - Article

SN - 0162-3257

VL - 44

SP - 1671

EP - 1680

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

IS - 7

ER -

Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11

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