Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials

Wendy A. Woodward; Robert G. Bristow; Michael F. Clarke; Robert P. Coppes; Massimo Cristofanilli; Dan G. Duda; John R. Fike; Dolores Hambardzumyan; Richard P. Hill; Craig T. Jordan; Luka Milas; Frank Pajonk; Walter J. Curran; Adam P. Dicker; Yuhchyau Chen

doi:10.1016/j.ijrobp.2009.03.047

Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials

Wendy A. Woodward^*, Robert G. Bristow, Michael F. Clarke, Robert P. Coppes, Massimo Cristofanilli, Dan G. Duda, John R. Fike, Dolores Hambardzumyan, Richard P. Hill, Craig T. Jordan, Luka Milas, Frank Pajonk, Walter J. Curran, Adam P. Dicker, Yuhchyau Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use. (C) 2009 Elsevier Inc.

Original language	English
Pages (from-to)	1580-1591
Number of pages	12
Journal	International Journal of Radiation Oncology Biology Physics
Volume	74
Issue number	5
DOIs	https://doi.org/10.1016/j.ijrobp.2009.03.047
Publication status	Published - 1-Aug-2009

Keywords

Stem cell
Radiation therapy
Cancer
Radiobiology
Clonogens
ENDOTHELIAL PROGENITOR CELLS
NEURAL PRECURSOR CELLS
BONE-MARROW
BREAST-CANCER
IN-VIVO
HIPPOCAMPAL NEUROGENESIS
TUMOR ANGIOGENESIS
SALIVARY-GLANDS
ADULT NEUROGENESIS
PERIVASCULAR NICHE

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10.1016/j.ijrobp.2009.03.047

Radiation Therapy Oncology Group Translational Research Program Stem Cell SymposiumFinal publisher's version, 285 KBLicence: Taverne

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Woodward, W. A., Bristow, R. G., Clarke, M. F., Coppes, R. P., Cristofanilli, M., Duda, D. G., Fike, J. R., Hambardzumyan, D., Hill, R. P., Jordan, C. T., Milas, L., Pajonk, F., Curran, W. J., Dicker, A. P., & Chen, Y. (2009). Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials. International Journal of Radiation Oncology Biology Physics, 74(5), 1580-1591. https://doi.org/10.1016/j.ijrobp.2009.03.047

@article{70c80dac214f49dd846449817b984443,

title = "Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials",

abstract = "At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use. (C) 2009 Elsevier Inc.",

keywords = "Stem cell, Radiation therapy, Cancer, Radiobiology, Clonogens, ENDOTHELIAL PROGENITOR CELLS, NEURAL PRECURSOR CELLS, BONE-MARROW, BREAST-CANCER, IN-VIVO, HIPPOCAMPAL NEUROGENESIS, TUMOR ANGIOGENESIS, SALIVARY-GLANDS, ADULT NEUROGENESIS, PERIVASCULAR NICHE",

author = "Woodward, {Wendy A.} and Bristow, {Robert G.} and Clarke, {Michael F.} and Coppes, {Robert P.} and Massimo Cristofanilli and Duda, {Dan G.} and Fike, {John R.} and Dolores Hambardzumyan and Hill, {Richard P.} and Jordan, {Craig T.} and Luka Milas and Frank Pajonk and Curran, {Walter J.} and Dicker, {Adam P.} and Yuhchyau Chen",

year = "2009",

month = aug,

day = "1",

doi = "10.1016/j.ijrobp.2009.03.047",

language = "English",

volume = "74",

pages = "1580--1591",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

publisher = "ELSEVIER SCIENCE INC",

number = "5",

}

Woodward, WA, Bristow, RG, Clarke, MF, Coppes, RP, Cristofanilli, M, Duda, DG, Fike, JR, Hambardzumyan, D, Hill, RP, Jordan, CT, Milas, L, Pajonk, F, Curran, WJ, Dicker, AP & Chen, Y 2009, 'Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials', International Journal of Radiation Oncology Biology Physics, vol. 74, no. 5, pp. 1580-1591. https://doi.org/10.1016/j.ijrobp.2009.03.047

Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials. / Woodward, Wendy A.; Bristow, Robert G.; Clarke, Michael F. et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 74, No. 5, 01.08.2009, p. 1580-1591.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium

T2 - Incorporating Stem Cell Hypotheses into Clinical Trials

AU - Woodward, Wendy A.

AU - Bristow, Robert G.

AU - Clarke, Michael F.

AU - Coppes, Robert P.

AU - Cristofanilli, Massimo

AU - Duda, Dan G.

AU - Fike, John R.

AU - Hambardzumyan, Dolores

AU - Hill, Richard P.

AU - Jordan, Craig T.

AU - Milas, Luka

AU - Pajonk, Frank

AU - Curran, Walter J.

AU - Dicker, Adam P.

AU - Chen, Yuhchyau

PY - 2009/8/1

Y1 - 2009/8/1

N2 - At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use. (C) 2009 Elsevier Inc.

AB - At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use. (C) 2009 Elsevier Inc.

KW - Stem cell

KW - Radiation therapy

KW - Cancer

KW - Radiobiology

KW - Clonogens

KW - ENDOTHELIAL PROGENITOR CELLS

KW - NEURAL PRECURSOR CELLS

KW - BONE-MARROW

KW - BREAST-CANCER

KW - IN-VIVO

KW - HIPPOCAMPAL NEUROGENESIS

KW - TUMOR ANGIOGENESIS

KW - SALIVARY-GLANDS

KW - ADULT NEUROGENESIS

KW - PERIVASCULAR NICHE

U2 - 10.1016/j.ijrobp.2009.03.047

DO - 10.1016/j.ijrobp.2009.03.047

M3 - Article

SN - 0360-3016

VL - 74

SP - 1580

EP - 1591

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 5

ER -

Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials

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