Radiopharmaceuticals for imaging chronic lymphocytic inflammation

Gaurav Malviya, Erik F. J. De Vries, Rudi A. Dierckx, Alberto Signore*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
224 Downloads (Pure)

Abstract

In the last few decades, a number of radiopharmaceuticals for imaging inflammation have been proposed that differ in their specificity and mechanism of uptake in inflamed foci as compared to the traditional inflammation imaging agents. Radiolabelled cytokines represent a reliable tool for the preclinical diagnosis of chronic inflammatory processes, even before anatomical and functional changes occur in affected tissues. Moreover, the introduction of radiolabelled monoclonal antibodies and sophisticated technique like PET/CT now make the field of inflammation imaging highly specific and accurate. In this review, different approaches of the established and experimental radiopharmaceuticals for imaging of chronic inflammation are discussed.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalBrazilian archives of biology and technology
Volume50
DOIs
Publication statusPublished - Sep-2007

Keywords

  • radiopharmaceuticals
  • inflammation
  • molecular imaging
  • PERIPHERAL BENZODIAZEPINE-RECEPTOR
  • POSITRON-EMISSION-TOMOGRAPHY
  • ACYLATED POLY-GALACTOSIDE
  • II ANTIGEN INDUCTION
  • B-CELL LYMPHOMA
  • RHEUMATOID-ARTHRITIS
  • IN-VIVO
  • MONOCLONAL-ANTIBODIES
  • E-SELECTIN
  • MICROGLIAL ACTIVATION

Cite this