Rapid pacing results in changes in atrial but not in ventricular refractoriness

BA Schoonderwoerd*, IC Van Gelder, RG Tieleman, KJ Bel, HJGM Crijns

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

It is well known that atrial tachycardia causes atrial electrical remodeling, characterized by shortening of atrial effective refractory periods (AERPs) and loss of physiological adaptation of AERP to rate. However, the nature and time course of changes in ventricular effective refractory periods (VERP) caused by rapid rates are to be established. After being instrumented with epicardial electrodes on both atria and both ventricles nine goats were subjected to 1 week of rapid AV pacing with a rate of 240 beats/min and an AV delay of 100 ms. Pacing was only interrupted for measurement of left and right AERPs and VERPs at three basic cycle lengths (BCL) of 400 ms, 300 ms, and 200 ms during sinus rhythm in the conscious animal. Left and right AERPs decreased at all BCLs, reaching minimum values after 3 days (right AERP at BCL of 400 ms, 96+/-16 ms after 3 days vs 144+/-16 ms at baseline, P

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalPace-Pacing and Clinical Electrophysiology
Volume25
Issue number3
Publication statusPublished - Mar-2002
Event21st Congress of the European-Society-of-Cardiology - , Spain
Duration: 28-Aug-19991-Sep-1999

Keywords

  • atrial fibrillation
  • arrhythmia
  • remodeling
  • pacing
  • TACHYCARDIA-INDUCED CARDIOMYOPATHY
  • INDUCED HEART-FAILURE
  • CHRONIC DOG-MODEL
  • ELECTROPHYSIOLOGICAL CHARACTERISTICS
  • SUDDEN-DEATH
  • FIBRILLATION
  • CARDIOVERSION
  • MECHANISMS
  • INDUCTION
  • HUMANS

Cite this