Rationale, design, and baseline characteristics of a trial of prevention of cardiovascular and renal disease with Fosinopril and Pravastatin in nonhypertensive, nonhypercholesterolemic subjects with microalbuminuria (the Prevention of REnal and Vascular ENdstage Disease Intervention Trial [PREVEND IT])

GFH Diercks*, WMT Janssen, AJ van Boven, AAA Bak, PE de Jong, HJGM Crijns, WH van Gilst, PREVENT IT Investigators

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

59 Citations (Scopus)

Abstract

This study describes the rationale, design, and baseline characteristics of a trial to determine whether treatment with fosinopril 20 mg/day and/or pravastatin 40 mg/day will prevent cardiovascular and renal disease in nonhypertensive (RR 10 mg/L once in an early morning spot urine and 15 to 300 mg/24-hour at least once in two 24-hour urine collections). The Prevention of REnal and Vascular ENdstage Disease Intervention Trial is a single-center, double-blind, randomized, placebo-controlled trial with a 2 x 2 factorial design. The 864 randomized subjects will be monitored for a minimum of 4 years and a maximum of 5 years. The primary efficacy parameter is defined as the combined incidence of all-cause mortality or hospital admission for documented (1) nonfatal myocardial infarction, (2) myocardial ischemia, (3) heart failure, (4) peripheral vascular disease, (5) cerebrovascular accident and/or (6) end-stage renal disease. (C) 2000 by Excerpta Medica, Inc.

Original languageEnglish
Pages (from-to)635-638
Number of pages4
JournalAmerican Journal of Cardiology
Volume86
Issue number6
Publication statusPublished - 15-Sep-2000

Keywords

  • CONVERTING-ENZYME-INHIBITION
  • ENDOTHELIAL DYSFUNCTION
  • ANTIHYPERTENSIVE DRUGS
  • ESSENTIAL-HYPERTENSION
  • DIABETES-MELLITUS
  • MORTALITY
  • ALBUMINURIA
  • PROTEINURIA
  • PREDICTOR
  • MORBIDITY

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