Reactive astrocytes in chronic active lesions of multiple sclerosis express co-stimulatory molecules B7-1 and B7-2

E Zeinstra, N Wilczak, J De Keyser*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

64 Citations (Scopus)

Abstract

Astrocytes in active lesions of multiple sclerosis (MS) express major histocompatibility (MHC) class 11 molecules, and may play an important role in the presentation of antigen to myelin-specific T cells.

However, it has been postulated that astrocytes are unable to act as antigen-presenting cells (APCs) because they would lack the B7 costimulatory molecules to activate these T cells. By using double labeling immunofluorescence staining, we demonstrate that reactive astrocytes in chronic active plaques of multiple sclerosis express the co-stimulatory molecules B7-1 and B7-2, and hence have the necessary attributes to act as antigen-presenting cells. (C) 2003 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalJournal of Neuroimmunology
Volume135
Issue number1-2
DOIs
Publication statusPublished - Feb-2003

Keywords

  • multiple sclerosis
  • co-stimulatory molecules
  • B7-1
  • B7-2
  • astrocytes
  • CENTRAL-NERVOUS-SYSTEM
  • ENCEPHALITOGENIC T-CELLS
  • IA ANTIGEN EXPRESSION
  • MYELIN BASIC-PROTEIN
  • CLASS-II MOLECULES
  • COSTIMULATORY MOLECULES
  • PROTEOLIPID PROTEIN
  • HUMAN MICROGLIA
  • IN-VITRO
  • GAMMA

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