Real-time stochastic detection of multiple neurotransmitters with a protein nanopore

Arnold J Boersma; Keith L Brain; Hagan Bayley

doi:10.1021/nn301125y

Real-time stochastic detection of multiple neurotransmitters with a protein nanopore

Arnold J Boersma, Keith L Brain, Hagan Bayley

Research output: Contribution to journal › Article › Academic › peer-review

63 Citations (Scopus)

Abstract

The detection of several different neurotransmitters with the same sensor in real-time would be a powerful asset to the field of neurochemistry. We have developed a detector for a broad range of neurotransmitters including amino acids, catecholamines, and nucleotides, which relies on the reversible binding of the analytes to a copper(II) complex within an engineered protein nanopore.

Original language	English
Pages (from-to)	5304-8
Number of pages	5
Journal	Acs Nano
Volume	6
Issue number	6
DOIs	https://doi.org/10.1021/nn301125y
Publication status	Published - 26-Jun-2012
Externally published	Yes

Keywords

Biosensing Techniques
Conductometry
Copper
Nanoparticles
Neurotransmitter Agents
Porosity
Protein Interaction Mapping
Stochastic Processes

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abstract = "The detection of several different neurotransmitters with the same sensor in real-time would be a powerful asset to the field of neurochemistry. We have developed a detector for a broad range of neurotransmitters including amino acids, catecholamines, and nucleotides, which relies on the reversible binding of the analytes to a copper(II) complex within an engineered protein nanopore.",

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KW - Conductometry

KW - Copper

KW - Nanoparticles

KW - Neurotransmitter Agents

KW - Porosity

KW - Protein Interaction Mapping

KW - Stochastic Processes

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Real-time stochastic detection of multiple neurotransmitters with a protein nanopore

Abstract

Keywords

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