Recent advances in Fenton and Fenton-like reaction mediated nanoparticle in cancer therapy

Huijie Han*, Jiachen Li, Hélder A. Santos*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Fenton and Fenton like reaction have been well clarified as efficient reactive oxygen species (ROS) sources in tumor, and have been widely developed into a cancer treatment method. Meanwhile, transition metal-based nanomaterials with Fenton or Fenton like reaction characteristics also have been well explored as therapeutic agents for the cancer therapy, mainly in chemo-dynamic and ferroptosis induced cancer therapy. Herein,to summarize recent advances in Fenton and Fenton like reaction mediated nanoparticles for cancer therapy, in this minireview, we first introduced the mechanisms of Fenton and Fenton like reaction and two therapeutic methods based on Fenton and Fenton like reaction, and then we introduced the well-designed nanoparticles with Fenton reaction or Fenton-like reaction characteristics for the cancer therapies. Finally its challenges and perspectives are discussed.
Original languageEnglish
Pages (from-to)40-51
Number of pages12
JournalBiomedical Technology
Publication statusPublished - Sep-2023


  • Fenton reaction
  • Fenton like reaction
  • Cancer therapy
  • Chemodynamic therapy
  • Ferroptosis

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