Recent advances in the catalytic asymmetric synthesis of β-amino acids

Barbara Weiner, Wiktor Szymanski, Dick B. Janssen, Adriaan J. Minnaard, Ben L. Feringa*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

409 Citations (Scopus)
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Abstract

In this critical review, the progress in catalytic asymmetric synthesis of β-amino acids is discussed, covering the literature since 2002. The review treats transition metal catalysis, organocatalysis and biocatalysis and covers the most important synthetic methods, such as hydrogenation, the Mannich reaction and conjugate additions.
Original languageEnglish
Pages (from-to)1656-1691
Number of pages36
JournalChemical Society Reviews
Volume39
Issue number5
DOIs
Publication statusPublished - 2010

Keywords

  • MANNICH-TYPE REACTIONS
  • ENANTIOSELECTIVE CONJUGATE ADDITION
  • CHIRAL BRONSTED ACID
  • TRANSITION-METAL CATALYSIS
  • HIGHLY EFFICIENT SYNTHESIS
  • BAYLIS-HILLMAN REACTION
  • AZA-MICHAEL REACTION
  • ONE-POT PROCEDURE
  • BETA(2)-AMINO ACIDS
  • ALPHA-AMINO

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