Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System

Huan Ye; Yang Zhou; Xun Liu; Yongbing Chen; Shanzhou Duan; Rongying Zhu; Yong Liu; Lichen Yin

doi:10.1021/acs.biomac.9b00628

Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System

Huan Ye, Yang Zhou, Xun Liu, Yongbing Chen, Shanzhou Duan, Rongying Zhu, Yong Liu, Lichen Yin

Research output: Contribution to journal › Review article › peer-review

206 Citations (Scopus)

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Abstract

Reactive oxygen species (ROS) play crucial roles in biological metabolism and intercellular signaling. However, ROS level is dramatically elevated due to abnormal metabolism during multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. By taking advantage of the discrepancy of ROS levels between normal and diseased tissues, a variety of ROS-sensitive moieties or linkers have been developed to design ROS-responsive systems for the site-specific delivery of drugs and genes. In this review, we summarized the ROS-responsive chemical structures, mechanisms, and delivery systems, focusing on their current advances for precise drug/ gene delivery. In particular, ROS-responsive nanocarriers, prodrugs, and supramolecular hydrogels are summarized in terms of their application for drug/gene delivery, and common strategies to elevate or diminish cellular ROS concentrations, as well as the recent development of ROS-related imaging probes were also discussed.

Original language	English
Pages (from-to)	2441-2463
Number of pages	23
Journal	Biomacromolecules
Volume	20
Issue number	7
DOIs	https://doi.org/10.1021/acs.biomac.9b00628
Publication status	Published - Jul-2019

Keywords

TELLURIUM-CONTAINING POLYMER
AMPHIPHILIC BLOCK-COPOLYMERS
RING-OPENING POLYMERIZATION
TUMOR OXIDATIVE STRESS
HYDROGEN-PEROXIDE
INTRACELLULAR DELIVERY
SINGLET-OXYGEN
CROSS-LINKING
DRUG-RELEASE
TRIGGERED DEGRADATION

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Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis SystemFinal publisher's version, 12.9 MBLicence: Taverne

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title = "Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System",

abstract = "Reactive oxygen species (ROS) play crucial roles in biological metabolism and intercellular signaling. However, ROS level is dramatically elevated due to abnormal metabolism during multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. By taking advantage of the discrepancy of ROS levels between normal and diseased tissues, a variety of ROS-sensitive moieties or linkers have been developed to design ROS-responsive systems for the site-specific delivery of drugs and genes. In this review, we summarized the ROS-responsive chemical structures, mechanisms, and delivery systems, focusing on their current advances for precise drug/ gene delivery. In particular, ROS-responsive nanocarriers, prodrugs, and supramolecular hydrogels are summarized in terms of their application for drug/gene delivery, and common strategies to elevate or diminish cellular ROS concentrations, as well as the recent development of ROS-related imaging probes were also discussed.",

keywords = "TELLURIUM-CONTAINING POLYMER, AMPHIPHILIC BLOCK-COPOLYMERS, RING-OPENING POLYMERIZATION, TUMOR OXIDATIVE STRESS, HYDROGEN-PEROXIDE, INTRACELLULAR DELIVERY, SINGLET-OXYGEN, CROSS-LINKING, DRUG-RELEASE, TRIGGERED DEGRADATION",

author = "Huan Ye and Yang Zhou and Xun Liu and Yongbing Chen and Shanzhou Duan and Rongying Zhu and Yong Liu and Lichen Yin",

year = "2019",

month = jul,

doi = "10.1021/acs.biomac.9b00628",

language = "English",

volume = "20",

pages = "2441--2463",

journal = "Biomacromolecules",

issn = "1525-7797",

publisher = "AMER CHEMICAL SOC",

number = "7",

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TY - JOUR

T1 - Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System

AU - Ye, Huan

AU - Zhou, Yang

AU - Liu, Xun

AU - Chen, Yongbing

AU - Duan, Shanzhou

AU - Zhu, Rongying

AU - Liu, Yong

AU - Yin, Lichen

PY - 2019/7

Y1 - 2019/7

N2 - Reactive oxygen species (ROS) play crucial roles in biological metabolism and intercellular signaling. However, ROS level is dramatically elevated due to abnormal metabolism during multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. By taking advantage of the discrepancy of ROS levels between normal and diseased tissues, a variety of ROS-sensitive moieties or linkers have been developed to design ROS-responsive systems for the site-specific delivery of drugs and genes. In this review, we summarized the ROS-responsive chemical structures, mechanisms, and delivery systems, focusing on their current advances for precise drug/ gene delivery. In particular, ROS-responsive nanocarriers, prodrugs, and supramolecular hydrogels are summarized in terms of their application for drug/gene delivery, and common strategies to elevate or diminish cellular ROS concentrations, as well as the recent development of ROS-related imaging probes were also discussed.

AB - Reactive oxygen species (ROS) play crucial roles in biological metabolism and intercellular signaling. However, ROS level is dramatically elevated due to abnormal metabolism during multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. By taking advantage of the discrepancy of ROS levels between normal and diseased tissues, a variety of ROS-sensitive moieties or linkers have been developed to design ROS-responsive systems for the site-specific delivery of drugs and genes. In this review, we summarized the ROS-responsive chemical structures, mechanisms, and delivery systems, focusing on their current advances for precise drug/ gene delivery. In particular, ROS-responsive nanocarriers, prodrugs, and supramolecular hydrogels are summarized in terms of their application for drug/gene delivery, and common strategies to elevate or diminish cellular ROS concentrations, as well as the recent development of ROS-related imaging probes were also discussed.

KW - TELLURIUM-CONTAINING POLYMER

KW - AMPHIPHILIC BLOCK-COPOLYMERS

KW - RING-OPENING POLYMERIZATION

KW - TUMOR OXIDATIVE STRESS

KW - HYDROGEN-PEROXIDE

KW - INTRACELLULAR DELIVERY

KW - SINGLET-OXYGEN

KW - CROSS-LINKING

KW - DRUG-RELEASE

KW - TRIGGERED DEGRADATION

U2 - 10.1021/acs.biomac.9b00628

DO - 10.1021/acs.biomac.9b00628

M3 - Review article

SN - 1525-7797

VL - 20

SP - 2441

EP - 2463

JO - Biomacromolecules

JF - Biomacromolecules

IS - 7

ER -

Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System

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Keywords

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