Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains

Fabien Aubry, Sofie Jacobs, Maïlis Darmuzey, Sebastian Lequime, Leen Delang, Albin Fontaine, Natapong Jupatanakul, Elliott F Miot, Stéphanie Dabo, Caroline Manet, Xavier Montagutelli, Artem Baidaliuk, Fabiana Gámbaro, Etienne Simon-Lorière, Maxime Gilsoul, Claudia M Romero-Vivas, Van-Mai Cao-Lormeau, Richard G Jarman, Cheikh T Diagne, Oumar FayeOusmane Faye, Amadou A Sall, Johan Neyts, Laurent Nguyen, Suzanne J F Kaptein*, Louis Lambrechts

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The global emergence of Zika virus (ZIKV) revealed the unprecedented ability for a mosquito-borne virus to cause congenital birth defects. A puzzling aspect of ZIKV emergence is that all human outbreaks and birth defects to date have been exclusively associated with the Asian ZIKV lineage, despite a growing body of laboratory evidence pointing towards higher transmissibility and pathogenicity of the African ZIKV lineage. Whether this apparent paradox reflects the use of relatively old African ZIKV strains in most laboratory studies is unclear. Here, we experimentally compare seven low-passage ZIKV strains representing the recently circulating viral genetic diversity. We find that recent African ZIKV strains display higher transmissibility in mosquitoes and higher lethality in both adult and fetal mice than their Asian counterparts. We emphasize the high epidemic potential of African ZIKV strains and suggest that they could more easily go unnoticed by public health surveillance systems than Asian strains due to their propensity to cause fetal loss rather than birth defects.

Original languageEnglish
Article number916
Pages (from-to)1-14
Number of pages14
JournalNature Communications
Volume12
Issue number1
DOIs
Publication statusPublished - 10-Feb-2021

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