Recent Developments in the Role of High-Mobility Group Box 1 in Systemic Lupus Erythematosus

Fleur Schaper*, Johanna Westra, Marc Bijl

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)
201 Downloads (Pure)

Abstract

High-mobility group box 1 (HMGB1) is an important molecule for several nuclear processes. Recently, HMGB1 has gained much attention as a damage-associated molecular pattern (DAMP) and has been implicated in the pathogenesis of several (auto)immune diseases, in particular, systemic lupus erythematosus (SLE). A main pathogenic feature in SLE is the accumulation of apoptotic cells. Since HMGB1 is released from apoptotic cells it has been hypothesized that HMGB1 might fuel the inflammatory processes, as seen in this disease, and play a fundamental role in the pathogenesis. In this review, we discuss evidence in support of the theory that HMGB1 is an important mediator in SLE and may be considered a new autoantigen.

Original languageEnglish
Pages (from-to)72-79
Number of pages8
JournalMolecular medicine
Volume20
DOIs
Publication statusPublished - 2014

Keywords

  • CONTAINING IMMUNE-COMPLEXES
  • ANCA-ASSOCIATED VASCULITIS
  • SERUM-LEVELS
  • APOPTOTIC CELLS
  • RHEUMATOID-ARTHRITIS
  • CYTOKINE RELEASE
  • DISEASE-ACTIVITY
  • PROTEIN HMGB1
  • HIGH-MOBILITY-GROUP-BOX-1 PROTEIN
  • RENAL MANIFESTATIONS

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